Jonathan Evan Shoag 🇮🇱🇺🇸

Jonathan Shoag, MD, @jeshoag is revitalizing old practices with cutting-edge innovation. Learn how advancements in PSA screening are reshaping care and improving outcomes for high-risk groups on the latest Science@UH episode: tinyurl.com/4ydu3u26

After analyzing insurance claims from 172,148 prostate biopsies (2016–2021), we found that sedation rates increased from 16% to 25%. 📈 A history of prior biopsy, saturation code, and MRI guidance were the strongest predictors🚨 Full article: ⬇️ @CaseUrology @jeshoag

The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to disease? These and other questions we will tackle within the SMaHT Network, now described in @Nature nature.com/articles/s4158…

Many men who survive cancer go on to become fathers; however, the effects of the treatment on sperm was unknown. @Shanypi1 @Camiloareg @jeshoag & team discover chemotherapy exposure is associated with an increase in new mutations in sperm of humans and mice:…

The study utilized high-fidelity duplex sequencing on chemotherapy-exposed individuals and controls. Results showed a marked increase in sperm mutations among those treated with chemotherapy.

Our new paper in @JCI_insight reveals that chemotherapy significantly increases the somatic mutation burden in sperm, raising important considerations for male cancer survivors regarding fertility and potential risks to offspring.

@UHhospitals @jeshoag shares expertise with @WSJ on debate about former President Joe Biden's late-stage prostate cancer wsj.com/health/joe-bid… via @WSJ

So proud to see some of our work finally out! This project meant a lot to me—it taught me so much, from IRB navigation to international collaboration and translational science. Grateful for the mentorship of @jeshoag. Coming back soon! @CaseUrology

@UHhospitals @UH_RE_Institute @DanSimonMD recognizes Urology Institute faculty David Sheyn @randy_vincejr @drrpope @HijazAdonis @jeshoag @LPonsky at 2025 UH State of Research Address. Together with industry, government and an innovative clinical and research staff, they lead the…

Happy to see our new paper out! A great collaboration with @jeshoag. We collected sequential sperm samples separated by decades, and used high-fidelity sequencing to measure germline mutation rates in individual men. nature.com/articles/s4146…

Out of press! 🚨 Prebx MRI use for PCa detection skyrocketed from 1.5% in 2012 to 30% in 2021—hitting 59% in men with prior bx! 📈 But access remains limited in rural areas. We also need clearer guidelines for bx-naïve patients!! @CaseUrology @jeshoag @JackMillot_

Appreciate the opportunity to represent @caseccc @UHhospitals at the Browns stadium to discuss spicy topics in bladder cancer

New Read! 📃 Advancing Understanding & Treatment of Prostate Cancer From a highly-coveted American Urological Association (@AmerUrological) Research Scholar Award to a $1.1 million Physician Research Grant from the Congressionally Directed Medical Research Program of the U.S.…

#NeverForgetOct7

Congratulations to @cwru's Shany Picciotto, PhD: recently selected as the @NCSAUA recipient of the @UrologyCareFdn's 2024 Research Scholar Awards! Dr. Picciotto - under the mentorship of Dr. Jonathan Shoag - will use the $80,000 in funding over two years to further examine the…

We show some new findings since the pre-print, including APOBEC3A's ssDNA cytosine deamination pattern and detection of SBS1 precursor lesions. See our pre-print thread for more info: x.com/giladevrony/st… Congrats to co-authors and thanks to our funders!

Now out @Nature, our paper on HiDEF-seq: single-molecule DNA sequencing that resolves single-strand changes (mismatches and damage)! go.nature.com/3KG7Njh