JCI insight
@JCI_insight
High-quality basic and translational research representative of all biomedical specialties and physician-scientists. Bluesky: https://jci-insight.bsky.social
No small potatoes! Martin E. Fernandez-Zapico & team @MayoClinic identify the nuclear envelope protein Emerin as a regulator of nuclear size in KRAS-driven pancreatic cancer. Complete report: insight.jci.org/articles/view/…
Tapping natural killer cells with N-803 as part of the cure strategy in HIV? @KevinEscandonMD @IDSAinfo @UMNews evaluate lymph nodes from ART-suppressed people with HIV after treatment with N-803 in a phase IB clinical trial. Full report: insight.jci.org/articles/view/…
Our collaborators unpacked a CD16 #polymorphism associated with #severe #covid19 Authors include: @skleinstein @bpeters @Rouphael_N @SesmaLab @JoannDArce @VivianaSimonLab Bali Pulendran, Mark Davis, Elias Haddad, Al Shaw, Elaine Reed insight.jci.org/articles/view/…
🚨 NEW PUBLICATION 🚨 "Pregnancy and lactation induce distinct immune responses to COVID-19 booster vaccination and SARS-CoV-2 breakthrough infection" from the Roan Lab in @JCI_insight. insight.jci.org/articles/view/…
CAR-T cell therapy for solid tumors remains limited. In this Review, Ruoqi Chen et al. discuss the latest advances in transcriptional factor engineering for empowering CAR-T cells with superior antitumor efficacy. insight.jci.org/articles/view/…
Caloric Restriction Promotes Resolution of Atherosclerosis in Obese Mice, while Weight Regain Accelerates its Progression jci.org/articles/view/… @JCI_insight
📰 Just published in @JCI_insight insight.jci.org/articles/view/… TL;DR: A new Thick Ascending Limb (TAL) cell classification shows this segment independently regulates: 🔷 Monovalent (Na⁺, K⁺) 🔶 Divalent (Ca²⁺, Mg²⁺) 👀 Fresh lens on TAL 👇
Set your sights on this! This issue’s cover features work by @StemCellsEh & team @IowaMed on an inexpensive, clinically translatable photoreceptor isolation strategy for the production of cell therapies to treat inherited blindness: insight.jci.org/articles/view/…
Immune therapy in cancer is often limited by adverse autoimmune effects including type1 diabetes. @MelissaGLechner @dgsomucla now discover the JAK inhibitor ruxolitinib protects against ICI-T1DM in mice and impairs T follicular helper cell differentiation in patients with…
Congrats to @UMPhysiology PhD student @JessicaMaung and the MacDougald lab for her paper in @JCI_insight showing metabolic dysfunction in lipodystrophy is improved by FGF21/sTGFBR2 gene therapy, but effectiveness depends upon environmental temperature. insight.jci.org/articles/view/…
ICYMI: Uncovering infectious agents often missed by conventional diagnostic testing for meningoencephalitis— Antonio C. da Costa & team identify diverse pathogens using metagenomic sequencing: insight.jci.org/articles/view/…
ICYMI: Parsing the STING in pulmonary hypertension— @ajbryantlab & team @UF report on opposing roles for STING in PH—a paradigm shifting mechanism suggesting we refocus on treatments that target cell-specific inflammatory activation: insight.jci.org/articles/view/…
Severe asthma can lead to airway obstruction due to airway remodeling, but the signaling was unclear. @JohnDDickinson1 @unmc now show the mTOR pathway is critical to this maladaptive epithelial response: insight.jci.org/articles/view/…
A protective genetic factor against severe COVID-19— @AnitaEQualls @oaaguilar503 @UCSF develop an assay to assess CD16A responses from clinical samples and identify a high-affinity CD16A polymorphism associated with reduced risk of severe COVID-19 Full report:…
JCI Insight - The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure insight.jci.org/articles/view/…