Hattie Chung

What do you do when grants are cancelled, faculty searches are frozen, and the ability to do the science you believe in is slipping out of reach? I wrote an essay. On efforts to solve aging with reprogramming, the primacy of the epigenome, and the path to rewriting our future:

A study in @NatMetabolism describes how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans. go.nature.com/442dd2p

Chuffed to share KRONOS: A foundation model for Spatial Proteomics! arxiv.org/abs/2506.03373 Exciting work with the indomitable @AI4Pathology, led by the amazing @mshaban_ai, @Yuzhou_Chang, with Huaying, @yeoyaoyu, @GuillaumeJaume, Andrew Song, and our collaborators

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:

Congrats to the authors ⁦@Yale⁩ on this exciting and important work! #BrainTCellsRule || The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour | Nature nature.com/articles/s4158…

Our latest paper on #cardiac #fibrosis is out today in @Nature. Congrats to @StanfordCVI @StanfordMed researchers led by @Sangkyun_Cho and @SiyeonRhee. And special thanks to computational scientists @GreenstoneBio for providing #AI #drugdiscovery. Link: nature.com/articles/s4158…

Today on the blog we introduce Cell2Sentence-Scale, which looks deep into how to best represent cells and biological information as text, opening up exciting applications for language-driven single-cell analysis with large language models. Learn more →goo.gle/4jC24dM

What if LLMs could “read” & “write” biology? 🤔 Introducing C2S‑Scale—a @Yale + @GoogleAI @GoogleDeepMind collab: we scaled LLMs (up to 27 B!) to analyze & generate single‑cell insights by turning transcriptomes into text 🧬➡️📝 🔗 Blog: research.google/blog/teaching-… 🔗 Preprint:…

Bio foundation models are great design and engg tools. But can they help decode the fundamental principles of life? We harnessed a single-cell FM for decoding the long-debated relationship between genome arch. and gene coregulation. It all started with an idle curiosity. 1/

The 2025 Breakthrough Prize in Life Sciences was awarded to: Drucker, Habener, Holst, Knudsen, and Mojsov for GLP-1/ozempic, Hauser and Ascherio for treating multiple sclerosis, and David Liu for CRISPR base editing. Terrific choices!

"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet" Our study highlighted in @Nature News nature.com/articles/d4158…

Our new #preprint on NK cell engineering is out! biorxiv.org/content/10.110… Using #CRISPR activation screens, we found a programmable mechanism to mobilize NK cells to breast cancer tumors by engineering these cells to express orphan and metabolite-sensing receptors. (1/11) The…

⚡️Really thrilled that #textgrad is published in @nature today!⚡️ We present a general method for genAI to self-improve via our new *calculus of text*. We show how this optimizes agents🤖, molecules🧬, code🖥️, treatments💊, non-differentiable systems🤯 + more!

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their…

Today in @Nature we share our back-to-back stories with @nzhenguw revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis…

Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵

Promoting healthy aging in women. Prolonging ovarian life. Slowing the onset of menopause. A feature @nature nature.com/articles/d4158… open-access And this week's editorial nature.com/articles/d4158…

The ovary might be the most remarkable example of tissue organization in the human body - dynamically remodeling itself hundreds of times across reproductive life. Let's learn how it's organized and how aging disrupts this orchestra. Megathread!🦣🧵

Grateful to have been included in this incredible project, alongside such an amazing team!