Gabriel Rocklin
@grocklin
High-throughput protein design and biophysics | Asst Prof, Northwestern Pharmacology @NuFeinbergMed @NUSynBio.
Small proteins can be more complex than they look! We know proteins fluctuate between different conformations- but how much? How does it vary protein to protein? Can highly stable domains have low stability segments? @ajrferrari experimentally tested >5,000 domains to find out!
What would our data landscapes look like if we could biochemically characterize 100s, 1000s, 10^n evolutionary sequences? Papers like this make strides towards that moonshot dream!! Such neat work from @MargauxPinney lab! science.org/doi/10.1126/sc…
"The body of data available in protein sequences is something fundamentally new in biology and biochemistry, unprecedented in quantity, in concentrated information content and in conceptual simplicity." - Margaret Dayhoff describing my research better than me before I was born
#MorganLabatND is hiring a research technician!! We are looking for an aspiring biochemistry researcher that shares our community values, is curious about the world around them, and brings a unique perspective to our team. (1/2) jobs.smartrecruiters.com/UniversityOfNo…
Gosh I used to be a bit of an LLM skeptic until I asked @Google #gemini what the best IdeS IgG protease is in pre-clinical testing! CYR212 in #autoimmunedisease
The NIH number is likely significantly larger than reported here. My own cancelled R35/MIRA lost all five years, but only the first just-awarded year was counted in the NYT total
Here Is All the Science at Risk @Harvard— including several of our own research grants. nytimes.com/interactive/20…
Do you want to use #bindcraft to use #ai to design mini protein binders for research? Are you worried about IP considerations but also want to get great results? Levitate.bio, part of @RosettaCommons is the only commercial provider
Should be required reading for all biology graduate students pubmed.ncbi.nlm.nih.gov/19782018/
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975
This is the most Israeli thing I’ve seen. Taken at the Weizmann Institute of Science, following the Iranian attack.
We are excited to share our new preprint, “An improved model for prediction of de novo designed proteins with diverse geometries”. (1/9) biorxiv.org/content/10.110…
Fine-tuning AF2 on the stable sequences’ Rosetta models improves predictions for geometrically diverse proteins across 5 protein folds. Fine-tuning on ~6k stable designs leads to better performance than fine-tuning on all 10k stable+unstable designs. (7/9)
🚀 Excited to release BoltzDesign1! ✨ Now with LogMD-based trajectory visualization. 🔗 Demo: rcsb.ai/ff9c2b1ee8 Feedback & collabs welcome! 🙌 🔗: GitHub: github.com/yehlincho/Bolt… 🔗: Colab: colab.research.google.com/github/yehlinc… @sokrypton @MartinPacesa
Huge congrats to Dr. Andrew Holston on a successful PhD defense!! Andrew has been working on the large-scale characterization and engineering of chimeric receptor histidine kinases. He’s looking for roles in biotech/academia, let’s connect if you’re hiring! -> @AlkynesOfSci
> be like hedy lamarr > forced into marriage with nazi arms dealer at 19 > husband takes you to military meetings thinking you're just pretty decoration > absorb all the weapons tech secrets while playing dumb blonde > escape nazis by drugging your maid, stealing her…
Suicide of a Nation. Top Universities like Harvard importing the world's genius into graduate research is how the USA remains an economic superpower. The self-inflicted destruction of our nation's power for domestic culture wars by fascists is possibly unparalleled in history.
Harvard is being held accountable for collaboration with the CCP, fostering violence, antisemitism, and pro-terrorist conduct from students on its campus.
Breaking one of the great engines of American progress and soft power as political payback for Harvard refusing unconstitutional demands
Breaking News: The Trump administration halted Harvard’s ability to enroll international students, a major escalation in its battle with the school. nyti.ms/3SLG7gW