Shiv Grewal
@grewalsh
Scientist; @theNASciences member; Alum @Cambridge_Uni; Studies Epigenetics; Views are my own
📢ACCESS DENIED!! Ever wonder how heterochromatin causes transcriptional gene silencing and is epigenetically inherited? Excited to share our new story showing that histone deacetylation, a conserved feature of heterochromatin domains from yeast to mammals, limits access to…
Huge congratulations @sakshi_singh29 on your publication! Excellent work!
Delighted to share our study that explores how Spt3 & Spt8, components of SAGA coactivator complex contributes to TBP recruitment in the Gcn4 transcriptome. Thanks to my mentor Dr. Alan Hinnebusch for his support. Read more via #NAR_Open academic.oup.com/nar/article/53…
Congratulations @SrivastavManjit!
#authorinterview Dr. Manjit Kumar Srivastav @SrivastavManjit working with Dr. Shiv I.S. Grewal lab @grewalsh @NIH talks about his work on "Pioneer transcription factor infiltration triggers de novo heterochromatin assembly" @MolecularCell . biopatrika.com/academia/resea…
So proud of you, @holla_sahana! Watching your journey has been such a joy. Wishing you all the best as you begin this exciting new chapter at TIFRH. They’re lucky to have you!
Thrilled to share that I’ve joined @TIFRH_buzz as an Assistant Professor! Deeply grateful to my mentors (esp @grewalsh and KN Balaji), colleagues, friends, family & EVERYONE who made this possible. Excited to explore Epigenetics & the 3D Genome with the brilliant minds in India!
Congratulations @rakesh_k_sahu
#authorinterview Dr. Rakesh K. Sahu @rakesh_k_sahu working with Dr. Shiv I.S. Grewal lab @grewalsh @NIH talks about his work on "Protecting heterochromatin from the remodeling machines" published in Molecular cell. biopatrika.com/academia/resea… via @biopatrika
It was an honor to speak at the Rockefeller University symposium celebrating David Allis—a true visionary who transformed the field of chromatin and gene expression. His legacy continues to inspire us all. Grateful to the organizers for such a meaningful and inspiring event.
Check out our new paper! ״Dynamic control of Dynamic control of Argonautes by a rapidly evolving immunological switch״ sciencedirect.com/science/articl… @CurrentBiology Contgrat Ethan!⚡️
1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 biorxiv.org/content/10.110…
Thrilled to share our latest work in @Nature! We show how cancer cells navigate DNA replication despite DNA damage, revealing new insights into genome stability. Huge thanks to my incredible collaborators! Check it out here: nature.com/articles/s4158…
Check out the latest work from our lab by Dr. Felicia Ebot-Ojong biorxiv.org/content/10.110…)
🎯 Our new laboratory preprint is out! Awesome collaboration with the labs @PabloFuentesP Gordon Hager, Juan F. Recio @PalomaPerez_IBV @PresmanLab and lead by incredibly talented @Andrea_AlegreM @AlbaJimP1 @aguslafuent @montseabella7 TJohnson 🎉🥳✨️
Happy New Year 2025! 🎉 As we step into another year of exploration and discovery, may curiosity guide us, innovation inspire us, and collaboration propel us forward. Here’s to breakthroughs, learning, and making the world a better place through science! 🌟 #HappyNewYear2025
Happy Thanksgiving! 🦃🍁 Wishing everyone a day filled with gratitude, love, and good food! Let’s take a moment to count our blessings and cherish the ones we hold dear 🧡 #Thanksgiving #Gratitude
The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. nature.com/articles/s4146…
Thank you, Ali! Hosting you and everyone at this fantastic symposium was a real honor. My sincere thanks to all the speakers for their thought-provoking presentations, and to the participants for contributing to such engaging and dynamic discussions!
It was wonderful to be part of the group honoring the memory and contributions of David Allis and Gary Felsenfeld to the field of chromatin biology and epigenetics at the National Cancer Institute. @theNCI Thanks to Shiv Grewal @grewalsh, and the organizing committee at NCI for…