Sile Hu
@fuopen
Interested in stats&pop genetics. He/him. Views are my own
Excited to see my project at @UniofOxford finally published at @NatureGenet ! Huge thanks to my co-authors @simon_r_myers @danjlawson @marchini @g_hellenthal @linoafferreira @ShiSinan , and the reviewers/editors. Read the publication here: nature.com/articles/s4158… 🚀🎉
Happy to share that our work from the @nmancuso_ lab is out in @NatureGenet! We developed SuShiE, a multiancestry fine-mapping method for molecular traits. doi.org/10.1038/s41588…
Postdoc position in my group in Tokyo! Please get in touch if you are interested. And happy to discuss projects - ranging from developing new methods to analysis of new genomes that we are now sequencing in the lab. riken.jp/en/careers/res… Lab page: speidellab.github.io
Amazing work, huge congrats, Hrushi
(1/6) Excited to share our manuscript describing Quickdraws, a novel algorithm and software to perform GWAS that increases association power while keeping computational costs low. More details below (thread). Link to article: nature.com/articles/s4158…
Very happy to share our new paper now on @medrxivpreprint: “Genetic risk effects act in sets”, a great effort led my PhD student @JolienRietkerk, and performed together with collaborators @andywdahl, @AndrewSchork, @jonathan_flint1 etc. Thread 1/n
The HLA region is key to human health, but is often excluded in large-scale GWAS. Informing future studies on its influence, @AJHGNews' latest article reports HLA haplotype-based associations across thousands of diseases: bit.ly/4lrJiXT #ASHG @jkpritch
Grok 4 is the first time, in my experience, that an AI has been able to solve difficult, real-world engineering questions where the answers cannot be found anywhere on the Internet or in books. And it will get much better.
Mutation-selection-drift balance models of complex diseases biorxiv.org/content/10.110… #biorxiv_genetic
I'm very happy that our paper on admixture in deep human evolution is out now in Nature Genetics! nature.com/articles/s4158… Thanks very much to my PhD supervisors Aylwyn Scally and Richard Durbin for their support throughout
VERY excited to announce a pre-print that represents the culmination of several years of work*: “On ARGs, pedigrees, and genetic relatedness matrices” doi.org/10.1101/2025.0… Led by @BrieucLehmann with contributions from @epigenci @LukeAnderTroc @jeromekelleher @petrelharp
A General Framework for Branch Length Estimation in Ancestral Recombination Graphs biorxiv.org/content/10.110… #biorxiv_evobio
Happy New Year! Our Twigstats paper is now out! nature.com/articles/s4158…
Kicking off the new year, our paper by @leo_speidel et al. is out describing what to me is a breakthrough in ancient genomics. By using genealogies to study ancestry we can get much more resolution to study finer-scale history. We call this method Twigstats.
GLEANR: Sparse matrix factorization of GWAS summary statistics robust to sample sharing improves detection and interpretation of factors with diverse genetic architectures biorxiv.org/content/10.110…
A consensus variant-to-function score to functionally prioritize variants for disease biorxiv.org/cgi/content/sh… #biorxiv_genetic
REGENIE v4.0 is live!🎉 You can now analyze time-to-event phenotypes, leveraging power gains with case-control phenotypes where time-to-event information is available. github.com/rgcgithub/rege…
Revealing the range of maximum likelihood estimates in the admixture model. biorxiv.org/cgi/content/sh… #biorxiv_genetic