Ethan Perlstein bio/acc
@eperlste
ceo @PerlaraPBC (@ycombinator W16), ceo @epalrestat, ceo @endrarediseases, solo vc @AngelList, evo pharmacologist, mTOR worshipper, cofounder of K&L
PMM2-CDG pioneer Maggie has been on epalrestat for almost two years as part of an ongoing single-patient IND study. Her first dose was January 2020. See the results with your own eyes 👇
hey @grok give me the top 100 accounts that are the biggest advocates for DeSci and @ them in your reply prioritize accounts talking about $RIF, $URO, $ART, $GOSSY, $EGS and @pumpdotscience also projects like @Big_Pharmai @BioProtocol @eterna_labs @endrarediseases…
1 in 10 Americans will be affected by a rare disease. But very few will get a drug. Even with current incentives for solving rare, most are still too small to fund. I spoke with YC biotech founder @eperlste about how crypto might be a new vehicle for funding rare. 🧵
Are the 10,000+ rare diseases considered a health crisis?
Summary of what we know so far about the FDA Commissioner’s National Priority Voucher (CNPV) Program: 1. The CNPV: > shortens the FDA review from 10–12m to 1–2m > allows sponsors to submit the majority of the application before the clinical trial is complete > will be reviewed…
ChatGPT agents for drug discovery not far off..
ChatGPT agent for investment banking:
The GENIUS Act passes the House by a huge margin, 307 - 122. The President will sign it into law tomorrow. We have stablecoin regulation in the USA 🇺🇸 A moment for celebration: the first major crypto bill done in Congress and an opening of the floodgates for value onchain 🎉
ChatGPT Agent: our first AI with access to a text browser, a visual browser, and a terminal. Rolling out in ChatGPT Pro, Plus, and Team today.
The value prop of DeSci for Pharma is making the US competitive with China on clinical trial speed and cost. Prove to TradBio that onchain decentralized trials run vastly cheaper and faster, then they’ll be all over crypto..
yah but yeast is still the hottest model organism
A tiny worm called C. elegans is a favorite among biologists. Studies of these wiggly worms have given surprising insights into human health and led to four Nobel Prizes. Learn more: bit.ly/4f05mXi
I would hope that the scientists attending a psychedelics conference are on the substances they study in the lab.
Pitting o3 vs Grok 4 against each other with identical prompts relating to biology specifically. So far not discerning much of a difference. Both are giving similar answers. Feels kinda like talking to a pair of identical twins who were separated at birth.
How are the 10,000+ rare diseases affecting 1 in 10 Americans NOT a national priority?
Marty Makary FDA Commissioner discusses the Commissioner's National Priority Voucher Program on CNBC: What qualifies as a national priority? 🔹Large unmet public health need. Would like to see: - cure for T1 diabetes - more cancer therapies for stage 4 metastatic disease -…
The biggest regret I have from my all-too-brief stint as CSO of @ReeveFoundation that was cut short by COVID was not being able to close a partnership with @neuralink. @maxhodak_,whom I knew from YC, was there at the time and we had just one promising intro meeting in late…
🚨NEURALINK IMPLANTS 7TH PATIENT, MEET JAKE SCHNEIDER Jake becomes seventh brain chip recipient targeting neurodegenerative diseases. Vows to "redefine what is possible" as Neuralink expands beyond paralysis patients. Source: @PairedWith_P7 @neuralink
The biggest regret I have from my all-too-brief stint as CSO of @ReeveFoundation that was cut short by COVID was not being able to close a partnership with @neuralink. @maxhodak_,whom I knew from YC, was there at the time and we had just one promising intro meeting in late…
🚨NEURALINK IMPLANTS 7TH PATIENT, MEET JAKE SCHNEIDER Jake becomes seventh brain chip recipient targeting neurodegenerative diseases. Vows to "redefine what is possible" as Neuralink expands beyond paralysis patients. Source: @PairedWith_P7 @neuralink
TradBio is wringing its hands over China eating its lunch, but completely asleep at the wheel on AI which will drive incalculable innovation from below.
Nothing stops this train
Bitcoin is hitting all time highs.
Curetopia Lab Meeting livestream will be on Monday July 14 @ 9AM PACIFIC We’ve been heads down cooking and we have the results to show for it. We’ll review ARS drug repurposing pipeline updates — join us! 🔗👇
Why stop at a kidney? Blood, sperm, and ovaries are fungible too!
Biotechs would say stuff like "we can't raise money" but founder still has 2 kidneys. Curious.
If the frontier models today can save 10 hours for every one of the 50M+ PhD scientist on Earth, that equates to a collective productivity unlock of 1000 millennia! We have no idea what’s coming, but it’s the biggest thing since sliced bread
This graphic doesn’t even represent the advanced AI models. What OpenAI or Google DeepResearch models can complete in 15-20 minutes would take me dozens of hours. I’m also testing a model that’s even much further ahead…what’s coming is a far bigger hurricane! I’ll keep warning☺️
This FDA is the most community engaged I’ve ever seen — take them up on their offer!
Got a question for the FDA Commissioner? In our next FDA Direct conversation, we'll be fielding questions from the audience. Click the link below to submit yours! fda.gov/news-events/in…