Phil Leung
@definitelyphil
Co-founder @Xaira_Thera | @UWProteinDesign PhD http://instagram.com/definitelyphil
My doctoral advisor @UWMolES / @UWproteindesign (and current scientific advisory board membe @Xaira_Thera) David Baker won the nobel prize!! So stoked and extremely determined to deliver on the promise of this tech! nobelprize.org/prizes/chemist…
Thrilled to share our latest publication in Nature: nature.com/articles/s4158…. This work reflects a fantastic collaboration—special thanks to David Baker and @TimothyPJenkins. Hoping it sparks attention to this neglected health issue and drives solutions in the years ahead!
We searched for Bigfoot using CRISPR. DNA storage meets CRISPR search: AI maps the data, Cas9 slices it, nanopores read it. Multiplexed molecular search with semantic retrieval across a database of DNA-encoded images. Off-targets = a feature, not a bug. tinyurl.com/mr34c7fh
So cool to see #CrispyShifty hinges applied this way! Congrats @adam_broerman
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.110…
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.110…
I guess errors are expected. But it does highlight the need for journals to require depositing source code before publication.
After taking a look at af3 released code… looks there are some differences to the Nature report😉 @maxjaderberg @pushmeet Also reported here github.com/bytedance/Prot…
⚛️ I got a new job ⚛️ After 5 wonderful years at @UWproteindesign and @UWMolES, I’m headed to Palo Alto for a postdoc at @StanfordUChem under Todd Martinez. SUPER excited to dive into deep learning for quantum chemistry and explore the Bay Area!!
Nobel Laureate David Baker on the phone with fellow awardees Demis Hassabis and John Jumper. The trio discussed how their teams have inspired one another and what the future may hold.
Congrats!!
Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…
Love this article by @schubertcm @geekwire on what we're trying to do here in #Seattle at @Xaira_Thera @JustasDauparas @naterbennett0 geekwire.com/2024/inside-th…
Excited to announce our new paper on designing allosterically regulated protein assemblies from scratch, now published in @Nature! This collaborative effort included key contributions from @FloPraetorius, Abbas Idris, @AnnikaPhilomin, @cweidle1 and others! nature.com/articles/s4158…
Awesome paper in @Nature! @ArvindSPillai1 achieved theoretically perfect ligand binding cooperativity with a hill coefficient of ~4 (hemoglobin is ~2.8 by comparison). Congrats Arvind, Abbas, @FloPraetorius and team, truly an honor to help with this work: nature.com/articles/s4158…
Hot off the press: New paper about computational design of oligomeric proteins that can be triggered to change size and shape through allostery. Check out the beautiful thread by @ArvindSPillai1 !
Excited to announce our new paper on designing allosterically regulated protein assemblies from scratch, now published in @Nature! This collaborative effort included key contributions from @FloPraetorius, Abbas Idris, @AnnikaPhilomin, @cweidle1 and others! nature.com/articles/s4158…
Congrats @SusanaVazTor it was an honor to work with you in grad school!
Yesterday we celebrated @SusanaVazTor for a thesis well defended! Neutralizing the 🐍
We’re thrilled to share our new pre-print exploring how we can design and control dynamic proteins! (1/6) biorxiv.org/content/10.110…
Excited to share that I am starting a lab focused on deep learning-based protein design, biophysics and fundamental biology at @MPI_Biochem and @GeneCenter_LMU in Munich with the Emmy Noether Programme this summer. Join us as a PhD or postdoc. More to follow soon!
I'm very excited to share the work I've been doing over the last year! Contributing to new therapies for snakebite victims and collaborating with amazing scientists has been incredible! researchsquare.com/article/rs-440… @TimothyPJenkins @UWproteindesign