Dan Weiner, MD PhD
@danweiner92
PGY-1 @mghmedres via @harvardMITmdphd @broadinstitute \\ co-host Beyond The Abstract podcast \\ human genetics in complex traits
Just as most heritability resides in variation ⬇️ genome-wide significance thresholds, so exists meaningful transcriptional variation in genes individually not identified as a genomewide sig. This new method TRADE from @NadigAjay @Luke0connor characterizes those effects!
How do genetic perturbations change cells? How are these effects shaped by cell type and dosage? How do we best extract insight from modern massive perturbation atlases? Im pleased to share a new preprint where we develop a suite of statistical approaches to these Qs (link below)
Great NEJM review on how human training and use influence output of medical AI
Excited to share this work published in @NEJM, exploring how human values influence the output of LLMs and clinical prediction models nejm.org/doi/full/10.10…
We've noticed some common missteps when using Burden Heritability Regression (BHR) If you're using BHR, take a look at this new FAQ to avoid them! github.com/ajaynadig/bhr/…
New episode out this morning!! Today @GFPtagged + @danweiner92 tell the remarkable story of one scientist's very personal journey to find a treatment for hyperemesis gravidarum (@DrFejzo @HGmoms) Listen wherever you get your podcasts, or link below: player.captivate.fm/episode/c193d5…
Wegovy is effective, but no Medicare coverage. Easy to assume because of high $. But all obesity meds = 30y restriction. Today in @statnews, I discuss how ban emerged in a very different environment and argue we should recognize origins of status quo. statnews.com/2024/01/08/wei…
Can we precisely rewrite the genetic code - make a single DNA spelling change - in the liver of a human being for clinical effect? YES! Scientific milestone: VERVE-101 provides first proof-of-concept for in vivo DNA base editing in humans Clinical implication: It’s early…
I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…
Out today @Nature – our analysis of the influences of common nuclear DNA variation on mitochondrial DNA copy number and heteroplasmy across >250,000 people across two biobanks! disq.us/t/4ibyjjo
Everyone should apply to be a part of this brilliant new HMS lab. Huge congrats Luke!
Thrilled to announce: I'm starting a faculty position in the HMS Department of Biomedical Informatics @HarvardDBMI! The O'Connor Lab is crossing the river. 1/
We're excited to share a new podcast this morning! Today, @GFPtagged + @danweiner92 discuss new research on the single most important genetic risk factor for Alzheimer's and its therapeutic potential. Listen wherever you get podcasts, or here 👇 player.captivate.fm/episode/c02ef4…