Rahul Gupta
@rahulg603
MD/PhD Student at @harvardmed and @MIT. Coadvised by @VamsiMootha and @bmneale. Interested in statistical genetics, mitochondrial biology, and disease.
Out today @Nature – our analysis of the influences of common nuclear DNA variation on mitochondrial DNA copy number and heteroplasmy across >250,000 people across two biobanks! disq.us/t/4ibyjjo
One of the most comprehensive and definitive pieces of work I’ve ever seen from one of the most intelligent scientists I have ever met. Huge, huge congratulations on this tremendous effort!!
Excited to see our paper out in @Nature last week! As part of a larger effort to develop a cell type atlas of the whole mouse brain, we built a brain-wide anatomic and transcriptomic atlas of adult mouse spinal projecting neurons (SPNs). (1/7) nature.com/articles/s4158…
Excited that our single-cell eQTL study of HLA genes is out now in @NatureGenet! ⭐️ nature.com/articles/s4158… Huge thx to @soumya_boston @saorisakaue @yluo86 for their guidance Check out this great News & Views by the Gaffney lab describing the key points: nature.com/articles/s4158…
I’m very excited to share our latest work on mapping eQTLs for classical HLA genes at single-cell resolution across >1K individuals and 1.14 million cells: medrxiv.org/content/10.110… with @soumya_boston, @saorisakaue, @yluo86 @mariaGTAC, and many other awesome folks.✨ Tweetorial👇
Very cool work by @rahulg603 @LabNeale @VamsiMootha, and delighted to contribute. Super cool new connections between mtDNA mutational burden in blood & clonal hematopoiesis 👇
As we all age, we accumulate mtDNA mutations, but what underlies this hockey stick pattern? See our new pre-print: we treat mtDNA SNV burden as a "trait" and use GWAS to uncover the mechanism in blood. Led by newly minted MD-PhD @rahulg603 w/ @LabNeale. shorturl.at/IqYY8
Some exciting news — I’ll be joining @ycombinator as a visiting partner for the Winter 2025 batch! Excited to be back in the YC community, working with the next generation of startups. 1/ ( 🧵)
Introducing a resource of mtDNA copy number (mtCN) across ~10k human donor-tissues (GTEx), 20 murine tissues, and 173 cancer cell lines. Insights emerge by integrating mtCN w/other large-scale measures, e.g., DepMap cells w/high mtCN resist loss of GPX4. pnas.org/doi/10.1073/pn…
4 years ago, we ran 16,554 GWASes for 7,271 traits across 6 ancestry groups and released the data to the public along with meta-analysis. After many careful dives through the results, we are happy to present these analyses on behalf of the Pan-UKB Project: medrxiv.org/content/10.110…
Continuing our study of the somatic segregation of pathogenic mitochondrial DNA variants. T cell activation selects against the m.3243A>G variant in a manner that persists with time/age. @VamsiMootha @broadinstitute @MGHNeurology @MGHMolBio pubmed.ncbi.nlm.nih.gov/38499449/
We are excited to share Genotype-Neighborhood Associations, GeNA, a new tool adapting our CNA framework to detect cell states associated in abundance with genetic variants at genome-wide scale in high-dimensional single-cell data w/ @soumya_boston doi.org/10.1101/2023.1… 🧵
Thrilled to share I’m opening my lab @YaleGenetics in 2024! Excited to join the faculty of this amazing department. We’ll study human genetic variation in health & disease focusing on mitochondrial genomics I’m #hiring, reach out if interested! #ASHG2023 thelakelab.org
12 tips for surviving and thriving in PhD-land! 🏔️ Thanks for the feature @behindthescope_ @careyjans (& obsessed with the artwork @S_Hunter_Chang)!
Today on the #BTMblog, @joycebkang shares 12 tips for thriving in your PhD. From selecting a lab to surviving the ups and downs of graduate training, read her post to glean some wisdom about #PhDlife. #sciencebehindthescenes behindthemicroscope.com/post/12-tips-f…
I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…
Health care is making Americans poorer. In @NEJM, we describe the current burden of medical debt, the history of our health financing system, and solutions to endemic medical debt in the US. nej.md/3P1X2tc 1/10
Very cool paper from @VamsiMootha @bmneale & @rahulg603! Variation in mtCN and heteroplasmy is controlled in large part by the genetic variation in the nuclear genome. Leveraging @AllofUsResearch and @uk_biobank sequencing data.
Today we report @Nature a biobank-scale analysis of #mitonuclear interactions, showing how our nuclear genotype impacts mtDNA copy number and even heteroplasmy! Led by @rahulg603 collab w/ @bmneale @broadinstitute @MassGeneralNews @harvardmed @HHMINEWS disq.us/t/4ibyjjo