Carl Raymund Salazar

Higher-order oligomeric assemblies are common across immune systems in all domains of life... 𝘽𝙪𝙩 𝙬𝙝𝙮!? 🤔 Using recent insights into bacterial immunity, we discuss the possible evolutionary advantages of these fascinating architectures🧬🏛️: rb.gy/cbwxxp 1/5

Mechanistic insights into Shedu antiphage nucleases! While the immune trigger(s) remain enigmatic, the modular N-terminal domain hints at varied infection sensing strategies. biorxiv.org/content/10.110…

Genome editing has revolutionized the treatment of rare disease. What if we could put any change into RNA safely and reversibly? Today we (+ @omarabudayyeh ) debut PRECISE, allowing for RNA edits, deletions, and insertions from 1 to >1,000nt biorxiv.org/content/10.110… 🧵 1/x

Happy to share our latest story revealing how type III CRISPR-Cas ancillary effectors tactically inhibit translation to combat phage infections: science.org/doi/10.1126/sc…. Here is a thread covering major points: (1/9)

Hard to believe it's been 2 years since we released PADLOC v1.0.0 😱. To celebrate, here's a new major release – 📦 PADLOC v2.0.0, with lots of new systems! 🔥 (available from GitHub/Conda and the PADLOC web server: padloc.otago.ac.nz) 🧵 1/n

Could not resist. Making that figure in 2019, I thought the newly uncovered diversity of antiphage systems was already incredible. We now know it was just the tip of the iceberg. I hope our new review will help people dive into this wonderful field. rdcu.be/dg3ql.

A mind-blowing paper has come out today in @Nature In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/sc…). Today, a group of scientists from…

Proud to report our work on Type IV CRISPR CasDinG is out today at Nucleic Acids Research! doi.org/10.1093/nar/gk… Notably, each student author (five) was at one time, or is currently, an undergraduate researcher in my lab. @UStateScience, @NAR_Open

Did you enjoy @crispr2023 or want to come to the next one! The #crispr conference will be in ⁦@Christchurch_NZ⁩ organised by ⁦@PeterFineran⁩, ⁦@dsashital⁩ ⁦@gavinjknott⁩ and ⁦@drbridgetwatson⁩. Check out the website crispr2025.org

#CRISPR2023 was a blast! It was so nice to meet awesome people in the field, see old colleagues again, and talk about all the cool science everyone’s doing. 🤯 Very inspiring, and looking forward to the next one already!

Excited to share my PhD work for discovery the new signal molecule SAM-AMP from CorA-associated type-III CRISPR system! Thanks so much @mfwhite2 and for the opportunity to present my work @crispr2023 biorxiv.org/content/10.110…

yeah it's kinda crazy these days but i'm sure it was never **easy** to publish in Nat,,, nature.com/articles/02348…

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in @Nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s4158…