Advanced Bioimaging Center @ UC Berkeley

1/ Better late than never, here’s a long thread of threads summarizing our MOSAIC preprint. If you’re curious about the process by which a new microscope is conceived and brought into the world, this is the thread for you. If you’ve come for eye candy, there’s plenty of that too…

Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.110… @Eric_Betzig @legant_lab

The MOSAIC reconfigurable microscope by @Eric_Betzig et al is finally out! MOSAIC integrates multiple advanced imaging techniques including light-sheet, label-free, super-resolution, and multi-photon, all equipped with adaptive optics: biorxiv.org/content/10.110…

Unlocking the potential to image petabyte-scale datasets 😵‍💫! From #CZBiohubSF Investigator Gokul Upadhyayula and co-corresponding authors & @BerkeleyMCB colleagues Xiongtao Ruan and @Eric_Betzig.

Almost everyone in microscopy (especially LSFM) talks about data deluge, but the tools haven't kept apace with the problems. Check out PetaKit5D for processing and analyzing your huge datasets!

Out today from Ruan, Betzig, Upadhyayula and colleagues! PetaKit5D offers versatile processing workflows for petabyte-scale light sheet microscopy data. nature.com/articles/s4159…

Neural space-time model (NSTM) was published this week in @naturemethods ! Check it out: nature.com/articles/s4159… It is a flexible and robust model to tackle motion blur and improve temporal resolution in computational cameras/microscopes.🧵👇

(1/x) We are excited to introduce VIPS (Volumetric Imaging of biological specimens via Photochemical Sectioning) in our preprint! VIPS uses a light-based process called “photochemical sectioning” to achieve petabyte-scale high/super-resolution imaging: biorxiv.org/content/10.110…

Nanoscale volumetric fluorescence imaging via photochemical sectioning biorxiv.org/cgi/content/sh… #bioRxiv

Origin of wiring specificity in an olfactory map: dendrite targeting of projection neurons biorxiv.org/cgi/content/sh… #bioRxiv

Imaging scientists are essential to accelerating biomedicine. 🔬 Thank you to our grantees and partners for a productive virtual convening this week. We’re grateful for your work! #ImagingTheFuture

Big congrats to Dong Li and their new paper in @naturemethods! 👏👏👏nature.com/articles/s4159… If you want to see what I think is the best scientific cat figure since Schrödinger's read our News & Views on the paper nature.com/articles/s4159…

Next time you are writing the microscopy methods section for a paper, consider encapsulating your configuration in an FPbase microscope as @JeeyunC et al did: sciencedirect.com/science/articl… Wouldn't you rather evaluate a microscopy setup like this? fpbase.org/microscope/H6Z…

A two month timelapse of the first Multimodal Optical Scope with Adaptive Imaging Correction (MOSAIC) build by a hard-working team at the ABC @UCBerkeley @berkeleyMCB @rxist525 @CShirazinejad @cziscience