Chang Liu
@chang_c_liu
Prof. at UC Irvine developing specialized genetic systems for rapid evolution, protein engineering, and biology at large. Also at http://chang-c-liu.bsky.social
Our work exploring the ability of and requirements for ML to predict the effects of mutations on antibody–antigen binding affinity (ΔΔG) is out now in @NatComputSci!
Out now! @AlissaHummer, @OPIGlets and colleagues present Graphinity, a method to predict change in antibody-antigen binding affinity (∆∆G). Featuring synthetic datasets of ~1 million FoldX-generated and >20,000 Rosetta Flex ddG-generated ∆∆G values! nature.com/articles/s4358…
Thank you to everyone who attended the 25th Annual UC Systemwide Bioengineering Symposium last week at UC Irvine!
Our latest story is now online @Nature! We discovered a phage defense system that deploys kilobase-long DNA homopolymers to protect against viral infection. Congratulations to all authors, and to the @WiedenheftLab for a fun and fruitful collaboration! nature.com/articles/s4158…
I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! youtube.com/watch?v=8YhJM6…
Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to @yuichi_furuhata, a true master bioengineer, on leading this excellent work! nature.com/articles/s4146…
🚨 New in @ImmunityCP ! EVE-Vax, an AI model that anticipates future viral evolution and designs antigens to proactively test vaccines + therapeutics—before variants even emerge. We envision this work will help make future-proofed vaccines and therapeutics. 👇 (1/7)
New in @ScienceMagazine, we present DISP—an imaging guided deep-tissue in vivo sound printing platform that allows spatiotemporally controlled printing of diverse biomaterials. Congrats to @DavoodiElham and the team! @Caltech @CaltechEAS @CaltechMedE science.org/doi/10.1126/sc…
🚨 Our lab just rewrote life‘s operating system! Together, we’ve built Syn57 - an E. coli with a synthetic genome running on a 57-codon genetic code! biorxiv.org/content/10.110… #SyntheticBiology #Syn57 #PhD #GeneticCode #GenomeEngineering #Biosecurity #FutureOfBiology
My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑🎓 Please RT. It's a great department with world-class expertise in all sorts of biomedical & biological engineering topics, including synthetic biology. 🇬🇧imperial.ac.uk/jobs/search-jo…
You’ve heard of vibe coding—meet vibe protein design. Click, launch, and watch the binders roll in. That’s what we're unveiling with @AriaxBio today.
In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️ @RachelSilvers11 @CGM_MGH @MGH_RI @MassGeneralNews @harvardmed nature.com/articles/s4158…
Exciting opportunity in @ADHansonLab!
#SyntheticBiology postdoctoral position in our group @ufhorticulture in directed evolution of enzymes that underlie important crop traits ⬇️