Claudia Mimoso

So excited to share that my thesis work is out now at @MolecularCell! Karen @AdelmanLab and I show that U1 snRNP increases RNA Pol II elongation rate within AT-rich introns, thereby reducing the likelihood of Pol II termination or arrest. Highlights below! authors.elsevier.com/c/1gobY3vVUPNx…

Happy to share this great review by co-authors @BaumofLife and Yu Ji on modeling human-specific regulatory functions in vivo, just out in Current Opinion in Genetics and Development! sciencedirect.com/science/articl…

I’m so excited to launch my independent career in a big way with the @NIH_CommonFund!! This is truly a testament to the wonderful mentors in my life and I hope I make them proud!

Interested in working on RNA processing and degradation? Come join us! My lab is recruiting at all levels!

I'm able to hire a second post-grad! If interested, please send me a cover letter + CV by October 1st

I’m excited to share that I’m starting a new position as a Yale School of Medicine Science Fellow in the Department of Genetics @YaleGenetics! I’ll be co-mentored by the Reinke and @Noonanlab Labs. Can’t wait to join the scientific community at Yale this Sept! @YaleSciFellows

I am so excited to share that I am starting this Fall as an Investigator at @LDI_ILD and Assistant Professor at McGill @McgillGBDO! I’ll be recruiting students and a research asssistant- Get in touch if you’re interested in chromatin and gene regulation! martinlab.ca

A new manuscript from the lab by graduate student @LVSoles ! 🧵 A nuclear RNA degradation code for eukaryotic transcriptome surveillance biorxiv.org/content/10.110…

Notch activation Promotes Pol2 Pause Release SWI/SNF comes before #ChromatinHaiku biorxiv.org/content/10.110…

I'm excited to share my manuscript describing our new insights into how Notch signaling induces transcription of target genes. Thanks to @BlacklowLab and @AdelmanLab and all co-authors! biorxiv.org/content/10.110…

A spatiotemporal map of co-receptor signaling networks underlying B cell activation dlvr.it/T7ynrF

Congratulations to twitter less Bonnie Su on her first paper from the lab! Bonnie shows that NELF can bind Pol II in two distinct confrontations that support either pausing or elongation. She did this using actively transcribing complexes. Read it here: authors.elsevier.com/sd/article/S10…

Online Now: Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing dlvr.it/T38kyQ

SAVE THE DATE! 02/22/24 for our Genetics Seminar Speaker Dr. Claudia Mimoso, PhD from Harvard University presenting “Defining the crosstalk between the transcription and splicing machineries.” Link below... medicine.yale.edu/event/gensem02… All @Yale affiliates welcome!

Congratulations Emily and all authors! It’s great to see such a clear role for NELF-mediated RNAPII pausing in spermatogenesis. Thanks to Prabu for introducing us to this cool system!

Happy to announce the final version of our paper is now available @NatureComms! nature.com/articles/s4146… Thank you to co-authors Kavya, @geoffmnelson @hdzomer, Debarun, Irene, Reza, Huanyu, @AdelmanLab and Prabu for a great collaboration of transcription and development expertise!

Fantastic to see our cohesin story now out @ScienceTM!! Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML: science.org/doi/10.1126/sc…

I'm glad that our paper on the anticancer compound JTE-607 has come out in 2023 in @NatureSMB ! Congrats to first authors Liang Liu and @angelamyu rdcu.be/dtqBa

Very much looking forward sharing our recent work on SWI/SNF! Thanks to the @CSMB_Trainees for the opportunity!

Your friendly neighborhood RNaseZap⚡️Ready to save all your RNA preps from RNases #BCMPRetreat @invitrogen

And @harvardmed has a great write-up on our story, with quotes from @AdelmanLab! hms.harvard.edu/news/one-punch…