Yongsheng Shi
@YongshengShi
Biologist at @UCIrvine, #RNA #stemcell #virology
Farewell to my talented tech Jack, who is going to start grad school at UCSF. It takes courage to start a research career at a time like this and look forward to the big things that he will accomplish!
Happy to introduce AlphaGenome, @GoogleDeepMind's new AI model for genomics. AlphaGenome offers a comprehensive view of the human non-coding genome by predicting the impact of DNA variations. It will deepen our understanding of disease biology and open new avenues of research.
Iron deficiency during early embryonic development can induce sex reversal, making an XY embryo grow ovaries instead of testes. Fascinating! The SRY gene (Sex-determining Region Y) located on the Y chromosome encodes a transcription factor that plays a key role in sex…
Postdoc positions are available for deciphering the nuclear RNA degradation code! Email me if interested! A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance: Molecular Cell cell.com/molecular-cell…
Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein. biorxiv.org/content/10.110… #cryoEM #transcription #splicing
RNA lovers, mark your calendar for this exciting meeting (August 19-23)! Abstract due: May 30 meetings.cshl.edu/meetings.aspx?…
Axonal RNA localization is essential for long-term memory: nature.com/articles/s4146…
A human gene makes mice squeak differently — did it contribute to language? Lovely article by @ewencallaway going into the contribution of human-specific NOVA1 variant to vocal communication nature.com/articles/d4158…
A new study from our long-term collaboration with Roger Sciammas' group @ucdavis studying the regulation of the alternative polyadenylation switch in IgM during B cell development! Distinct plasmablast developmental intermediates produce graded expres... sciencedirect.com/science/articl…
Start the new year with a new publication! Led by the talented postdoc @YoseopYoon ! RBBP6 anchors pre-mRNA 3′ end processing to nuclear speckles for efficient gene expression: Molecular Cell cell.com/molecular-cell…
Bravo to Wendell Lim, PhD, and team for making the cover of @ScienceMagazine! The team armed immune cells with “molecular GPS” to find and treat brain cancer, MS and type I diabetes. Clinical trials could begin as soon as 2025. @CDI_UCSF @ARPA_H @theNCI tiny.ucsf.edu/BeJ9N2
An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways…
Congrats Valérie!
Very proud to have been awarded an ERC Consolidator grant for research on neuronal RNAs! Rock on, team!
Looking forward to this meeting that brings together scientists from academia and industry! conferences.nature.com/r4VPMo?sms=2
Beautiful work! Congrats!
New Lab Preprint!🥳 Using CRISPR-Translate, a genome-wide CRISPR-Cas9 knockout screening method developed by the lab exploiting translation levels as a readout, we reveal that PACT is an inhibitor of PKR and not an activator during RNA viral infections. biorxiv.org/content/10.110…
I’m thrilled to share this story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. science.org/doi/10.1126/sc…