Linna An
@alchemist_an
Computational biochemist | Protein designer @UWproteindesign & natural product biochemist @ChemistryUIUC | bring academia goods to transformative products
Check out how we use ML-assisted method to design small molecule binders (binder to polar and flexible ligands as well!) and turn binding to sensing via CID and nanopore. @UWproteindesign Art credit to @ichaydon | Science dlvr.it/T9mdkM
Congratulations to @BingxuL Nathan, and @jBonzaniniSci ! Great work on developing pMHC binders! Design of high specificity binders for peptide-MHC-I complexes biorxiv.org/content/10.110…
It’s out! This is the version proved to be pretty powerful for both ligand binder design and enzyme design!
Late, but got it done. Inference and training code for CA RFDiffusion is available here: github.com/baker-laborato… Please have fun. Getting this online was an adventure, to say the least.
Without its international students, Harvard is not Harvard. hrvd.me/IntStudents25t
Harvard will continue to defend against illegal government overreach aimed at stifling research and innovation that make Americans safer and more secure. Read the full statement: hrvd.me/d24cca
New enzymes can unlock chemistry we never had access to before. Here, we introduce RFdiffusion2 (RFD2), a generative model that makes significant strides in de novo enzyme design. Preprint: biorxiv.org/content/10.110… Code: coming soon Animation credit: x.com/ichaydon (1/n)
Any billionaires with no idea what to do w/ their 💰 money? This could be your chance to stop the death of science, technically and innovation in America. Lots of PhD programs are being cancelled or reduced significantly in size across America... 🫣 wbur.org/news/2025/03/1…
NIH cuts are hitting young scientists the hardest. By David Baker. timmermanreport.com/2025/03/david-…
Amazing!!!!!
Anna and Sam figured out subtle geometric details of serine hydrolase active sites, and then figured out how make new proteins which fold up to reconstruct those active sites with sub-angstrom accuracy and catalyze ester hydrolysis. They are absolutely savage and inspiring.
Totally with @sokrypton. There are medical crisis, wealth gap, …, clearly AI can help, clearly previous US strategy didn’t work, why not let codes return to its original status, be open, be a big friendly community, and focusing on solving real world problems!
This seems like the wrong strategy, shouldn't we be rewarding openness instead of punishing it? 🤔 It's time for these closed-source ai companies to give back & share their code/resources w/ the international community. This could be a moment of unity, not further division.
Totally!!!
No need to pay $200 to use Operator You can create an agent that uses a web browser without writing a line of code. Combine DeepSeek R1 and Browser Use (free and open source) and you're good to go. (Links and prompt below)
Really cool GPCR binder! Both agonist and antagonist. State-specific Peptide Design Targeting G Protein-coupled Receptors biorxiv.org/content/10.110…
Congratulations to the team @sa_rettie, @DaveJuergens, @VAdebomi , *RFpeptides* is really cool method for all peptide chemists! Accurate de novo design of high-affinity protein binding macrocycles using deep learning biorxiv.org/content/10.110…
Impressive work! Congratulations to Adam!
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.110…
Everyone you need to see are here for protein designers.
Come see the scientists that should've shared the Nobel Prize for "Computational Protein Design", speak: ipd.uw.edu/protein-design…
Excited to be at #2024AIChE AIChE - between 10/26-28 at San Diego. I will be at #FacultyCandidate sessions (10/27 1 pm). Find me to talk about my plans on using ML for protein design on enzymes and sensors! (or just chat) Thx AIChE for supporting my 1st aiche meeting!
Nice photo. Great to be part of it! 😆
As researchers, innovators, and communities worldwide celebrate this remarkable achievement, we look forward to the groundbreaking discoveries and life-changing solutions that still lie ahead—solutions made possible by the visionary work that has earned David Baker a Nobel Prize.
Congratulations to David and all protein designers!
Nobel Laureate David Baker on the phone with fellow awardees Demis Hassabis and John Jumper. The trio discussed how their teams have inspired one another and what the future may hold.
Computing the Human Interactome biorxiv.org/content/10.110… Jing, @IanRHum, Qian, amazing work!
Thanks to all the organizers!
Welcome to our 20 Rising Stars on the first day of the workshop!