Adam Butterworth

Excited to see our GWAS meta-analysis of NMR metabolic biomarkers in 136,000 participants from 33 datasets out in Nature nature.com/articles/s4158… after years of work by many people, esp. @savitakartik @ClareOliverWil1 @eliasallara @mak_sysepi @johanneskettune & Minna Karjalainen

Excited to share our latent factor approach for high-dimensional trait #GWAS + #finemapping out in @CellGenomics doi.org/10.1016/j.xgen… Uses summary-level data. Software: github.com/jennasimit/fla… @FZ_Cambridge @WilliamAstle @aidanbutty @MRC_BSU @CAMBRIDGE_CEU

We are presenting our protein QTLs discoveries at #ESHG2025 #Poster P18.004.C. | May 26 | 1:00PM This project is led by a our great team manager Solène Cadiou at @humantechnopole in collaboration with Cambridge Univ. and @EuracBiomed

What risk factors are associated with premature heart attack in Bangladesh? Our case-control study with 8133 Bangladeshi patients found many local risk factors, interestingly risk was highest with the local practices of tobacco consumption 🔗Read more here tinyurl.com/yz6repy9

Can genetics affect our iron levels and what impact can this have on our health? @eliasallara and colleagues explored how the body controls iron and highlight how having too much or too little can negatively impact health Read more here 👉 tinyurl.com/h5yk3sfb

Excited for your return to Cambridge Kim!

🚨We're recruiting! Interested in making science and computing more environmentally friendly? Now is the time! Very excited to build a research group at @Cambridge_Uni to expand our Green Algorithms work thanks to the support of the @wellcometrust green-algorithms.org/join-us/

📢Fully-funded PhD studying the comorbidities of high adiposity. 🔗: jobs.cam.ac.uk/job/48333/ (2 weeks left, due November 20) Great work environment @CAMBRIDGE_CEU @HLRI_Cambridge, collab with @AstraZeneca @MikeXiao_JIANG @CambridgeATS. DM or e-mail for informal enquiries.

What geneticists fear the most: The Cambridge Plot.

Out in @NatureComms! Abdominal aortic aneurysm is a serious condition where the abdominal aorta enlarges & can rupture CEU colleagues used a polygenic risk score (PRS) to investigate the genetic risk & if you can use PRS to inform age for screening 🔗 tinyurl.com/mr3mupbc

Delighted to see this out nature.com/articles/s4146… in @NatureComms - we ran GWAS of 42 quantitative blood test traits in up to 40k British South Asian @GenesHealth participants. You can our findings using the browser benjacobs.shinyapps.io/gh_quant_trait… Code: github.com/benjacobs12345…

GWAS for Nobel prize laureates.

🚨🚨New paper alert 🚨🚨 nature.com/articles/s4225… rdcu.be/dVak3

Interested in a 4-year PhD studying the genetics of BMI and comorbidities? Don't wait, apply for my @AstraZeneca-funded studentship w/ @MikeXiao_JIANG 🔗: jobs.cam.ac.uk/job/48333/ (due October 31)! @CAMBRIDGE_CEU @HLRI_Cambridge @Cambridgecardio @DPHPC @CambridgeATS

The Open Targets Platform autumn release 🍁 is full of new data and UI features. This is the last update before we make a giant leap forward in our common genetic evidence 🧬

Check our paper in @Nature nature.com/articles/s4158… This is a huge collaborative work combining great basic and clinical science, with important implications for the prevention of atherosclerotic cardiovascular disease. Thanks to all our collaborators and funders!

Are you a Health Data Scientist looking to teach the next generation? The @DPHPC @MRC_BSU @MRC_Epid MPhil Population Health Sciences is looking for a Senior Teaching Associate to contribute to the course! 🔗: jobs.cam.ac.uk/job/47728/ cc: @HDR_UK Cambridge

Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease medrxiv.org/cgi/content/sh… #medRxiv

Excited to share our latest paper, where we describe ITSN1 as a novel risk gene for Parkinson's disease! We found that rare loss-of-function variants are associated with a 10-fold increased odds of PD. As far as we know, this is the largest effect size reported for sporadic PD…

In a preprint from the @23andMeResearch team, we used Mendelian randomization to explore the genetically-predicted causal effects of Lp(a) on a range (n=489) of human traits and diseases. medrxiv.org/content/10.110…

Want to use a cardiovascular disease🫀risk score for primary prevention, but unsure which is the best for your population?🧐 Our work compares CVD risk scores & provides a framework for selecting the most appropriate score. Just out in @LancetGH!👀⬇️ doi.org/10.1016/S2214-…