Ben Jacobs
@ben_m_jacobs
https://bsky.app/profile/ben-meir-jacobs.bsky.social
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence "implications are profound" New @Nature nature.com/articles/s4158… nature.com/articles/d4158…
Congrats @alvarfparis Great to see this out
A new study examining the connection between depression and dementia provides critical insights into how #depression might be both a risk factor for and an early sign of #dementia.
Today we’re launching the world’s most comprehensive study of proteins circulating in our bodies, which will transform research into new medical tests, drugs and treatments. Discover more: ukbiobank.ac.uk/learn-more-abo…
There is discrepancy between self-reported and objectively assessed cognitive functioning in #MultipleSclerosis, suggesting we shall use networks of PROMs and cognitive domains. Study from @maureen_dam @MScentrum020 @amsterdamumc @UniLeidenNews ▶️ journals.sagepub.com/doi/full/10.11…
Looking for new post doc role in 2026? 3 year contract working on proteomic data for AD and PD in Oxford. Do get in touch with any questions - would love to hear from you.
Dr Laura Winchester @Winchy_l at the University of Oxford is seeking a Post-Doctoral Researcher: Statistical Genomics and Machine Learning. Closing date: 10th January dementiaresearcher.nihr.ac.uk/job/post-docto…
✅ The UKB-RAP Transition Credits Programme is now open! Thanks to @wellcometrust, researchers can apply for £1,000 credits to help cover costs of using our data, with enhanced support available. Apply now & accelerate your research! More info: ow.ly/EHSs50Uq2qy
The newest @RegeneronDNA method, REMETA, from Tyler Joseph, @marchini, and co. is a game changer - enabling the ability to reconstruct gene-based test associations from single variant summary statistics (and LD).
Introducing a new method called REMETA from the Regeneron Genetics Center (RGC) @RegeneronDNA for meta-analysis of gene-based tests using summary statistics rgcgithub.github.io/remeta/ This is great work from Tyler Joseph. Pre-print is here medrxiv.org/content/10.110…
Introducing a new method called REMETA from the Regeneron Genetics Center (RGC) @RegeneronDNA for meta-analysis of gene-based tests using summary statistics rgcgithub.github.io/remeta/ This is great work from Tyler Joseph. Pre-print is here medrxiv.org/content/10.110…
Tandem repeats (TR) are usually underxeplored in genetic studies🧬 Here, a PheWAS of TRs in UK Biobank 👉N=168,554 👉47 TRs show significant associations with 73 traits 📜paper: nature.com/articles/s4146…
📢Please, RT: do you need to run GWAS, their imputation/meta-analyses/follow-up, PRS & MR? Apply for Short online live course "Introduction to GWAS" by Dec 20, 2024 tinyurl.com/y582m6ud 12th edition, over 530 scientists trained thus far! @eshgsociety supports fellowships
GxDrug interactions now published at cell genomics :) @sadowskimich did a ton of great work in this paper. We hope the approach is a step toward improving predictions for individual-specific treatment response
Our work using gene-environment interaction methods to study the genetics of drug response is now out in @CellGenomics. @CellPressNews cell.com/cell-genomics/…
"GWAS of Extended Prescription Analgesic Use Identifies Novel Genetic Loci in Chronic Pain" medrxiv.org/content/10.110…
Please RT! This was such an enjoyable event last year. Registration now open. Free registration for early careers researchers and clinicians in training who submit an abstract
🧵1/2 Registration & abstract submission is now open for Neuroimmunology & MS 2025. Back by popular demand this 2-day meeting is focused on neuroimmunology & MS. Numbers are limited so register now! edin.ac/3NVD9UN #neuroimmunology_MS_25 #research #education
One of the strongest risk loci for SLE lies on the MHC region. Earlier work by Steve McCarroll's group (Kamitaki et al Nature 2020; nature.com/articles/s4158…) used African ancestry samples to break down the LD between HLA and Complement gene variants and showed that the risk locus…
Glancing through a review of SLE genetics (tandfonline.com/doi/full/10.10…), I bumped into a familiar plot, which made me revisit the beautiful work by Kamitaki et al. from 2020 on the elegant dissection of the HLA GWAS signal (nature.com/articles/s4158…), which is one of the fine…
This is great news (COI: I am a long established consultant and shareholder to @nanopore) - epigenetic information on long reads at scale! (bonus - also excellent SV resolution coming our way). Haplotype methyl+hydroxymethyl resolution. 50,000 and then hopefully the full 500,000.
Today a landmark genetics partnership between @UK_Biobank, @nanopore, @SciTechgovuk, @GenomicsEngland and @NHSEngland to better understand the root causes of cancer and dementia has been announced. Find out more: ukbiobank.ac.uk/learn-more-abo…
In a cohort of 51,170 South Asians, #PolygenicRiskScores identified genetic susceptibility to insulin deficiency and fat distribution as key factors in young onset #Type2Diabetes and its rapid complications. #DiabetesPrevention #ChronicDiseases nature.com/articles/s4159…