Joanna Achinger-Kawecka

NEW preprint led by @ElyssaCampbell4 with @suscla1, where we used MOFA+ to uncover the rapid 3D chromatin and transcription changes triggered by androgens in prostate cancer. (1) Check it out here: biorxiv.org/content/10.110…

Excited to share our latest study published in Nucleic Acids Research: academic.oup.com/nar/article/53… It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate CTCF’s constant struggle in shaping the 3D genome architecture.

Pre-print from our lab! Led by Macsue Jacques who covered tissue-specific vs shared DNAm signatures across 17 human tissues -and discovered new hubs of genes previously unexplored in the ageing field. Thanks to many collaborators! @AgingBiology biorxiv.org/content/10.110…

Finally out today in nature.com/articles/s4158… 3D chromatin reorganization in prostate cancer lineage transformation, critically regulated by Nkx2-1 transcriptional network.

🚀 Calling all cancer researchers! Our 2025 Cancer Research Grant is now open. Apply for a chance to receive up to $10,000 in kits, services, and expert support. Advance your work in #3DGenomics, biomarker discovery, and precision medicine. Open to all career stages. Deadline:…

Our paper on deep single-cell DNA methylation analysis is out in Nature Communications rdcu.be/evfJm. Super elegant work by Nathan Spix describing replication dynamics, X-inactivation, and cell lineage identification.

Our scMicro-C paper is out in @NatureGenet! Huge thanks to the reviewers for their valuable insights, to @XieSunney for unwavering support, and to fantastic collaborators @JiankunZhang21 & @tanlongzhi. Thrilled to share this work!

Epigenetics Update - Disruption of TAD hierarchy promotes LTR co-option in cancer go.nature.com/4l70hOT #Epigenetics #Cancer #Chromatin #TADs --- Perfect for cancer, immunology, and aging research; epigenometech.com

DESpace2: detection of differential spatial patterns in spatial omics data biorxiv.org/content/10.110…

Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer @NatureComms rdcu.be/euijO Team science led by Kei Mizuno #BeltranLab @DanaFarber_GU @PCF_Science

The Cold Spring Harbor Asia (CSHA) meeting - Nuclear Architecture and Function is coming up soon! (Sept 1-5, 2025). Abstract submission deadline extended to July 18. Fantastic speakers & beautiful city (Suzhou) with Royal Garden. Check out here: csh-asia.org/?content/2743

A must read for young scientists! A career in science requires a thick skin. embopress.org/doi/full/10.10…

New online! Structural variants in the 3D genome as drivers of disease bit.ly/44FiIo5

RT please 🙌 Applications for a postdoctoral position in *Bioinformatics* in my lab are still open! Come and work with us @ARMI_Labs at the beautiful @cityofmelbourne Apply here careers.pageuppeople.com/513/cw/en/job/… Inquiries: [email protected]

Now online in @CD_AACR: AAnet Resolves a Continuum of Spatially-Localized Cell States to Unveil Intratumoral Heterogeneity - by Aarthi Venkat, Scott Youlten, @BeatrizPerezSJ, @KrishnaswamyLab, @c_chaffer, and colleagues doi.org/10.1158/2159-8… @Yale @YaleMed @GarvanInstitute

Congratulations to @ShellainaGordon @florian_perner on this exciting study which was a fantastic collaboration between @Armstrong_dfci and @TheDawsonLab @PeterMacRes @GenCancerCentre - we hope to see this clinically translated soon! aacrjournals.org/cancerdiscover…

Our newest paper is out today in PNAS! Small-molecule disruption of androgen receptor–dependent chromatin clusters pnas.org/doi/10.1073/pn…

Don't forget to register for #EREHD25! Our talk submission deadline has been extended to 12 JUNE 2025, so submit your abstract today to join our incredible speaker line up in Mexico this November 🇲🇽 🔗bit.ly/4kHWbw0

New in @CD_AACR! 👏 Dr. Ruth Scherz-Shouval and colleagues unravel a pathway of CAF-mediated suppression of NK cells in #BreastCancer, opening possible avenues for new biomarkers and strategies for immune-based therapies. #TumorMicroenviromment 🔗 bit.ly/3ZdI9dx

🚨 New meeting this fall in Brussels! 🚨 Cutting-edge science, amazing colleagues, & a RARE career development workshop for trainees-covering pharma, consulting, writing, start-ups & more 🤩 #epigenetics2025 Registration is open!! @epicypher @FuksLab xcellsconferences.com/epigenetics2025

Our new review is now online: everything you wanted to know (at least what is known in this nascent field) about promoter-enhancer locus dynamics but were afraid to ask. Great work @_mar_na! sciencedirect.com/science/articl…