Extracellular Matrix News

💡 Scientists at @unil found that glutamine synthesis by CAFs promotes the polarization of pro-tumorigenic TAMs and supports tumor growth by altering TAM composition, highlighting the pivotal role of CAFs in shaping the immunosuppressive TME. @JExpMed | bit.ly/4lFVTXt

🧪 Methacrylated collagen peptide-xanthan gum bioinks were developed for bioprinting stable constructs and were found to support human bone marrow #mesenchymal stem cell proliferation and differentiation with potential for ligament tissue engineering! 🔗 bit.ly/4okeKJA

👁️ To illustrate the potential of collagen patterning, a functional corneal stromal substitute is fabricated that mimics the microstructures of #collagen in cornea-sclera and demonstrates that it can restore histological structure and function. 👉 bit.ly/40VGp9J

Scientists present a detailed analysis of #scaffolds coated with specific membrane components or entire cell membranes, with applications in skin and #WoundHealing, bone regeneration, neural repair, and vascular grafts. 🩹 🤩 Check it out: bit.ly/413m3Ls

Cancer associated fibroblasts (CAFs) have been implicated in the pathogenesis of tumor #cachexia through their ability to modulate inflammation, metabolic reprogramming, and immune responses. Learn more in this new review! 📚 bit.ly/3GOT8nC

Investigators developed a cochlear #organoid culture system using synthetic GelMA hydrogel. They observed that the #ECM underwent rapid and extensive remodeling during the early phase of organoid self-organization. | @acsnano 👉 Give it a read: bit.ly/44SUHZS

Researchers including Drs. Andrea Brendolan and Paolo Ghia developed a novel in vitro 3D lymph node-like spheroid model of the leukemic microenvironment by culturing human #ChronicLymphocyticLeukemia cells with #fibroblastic reticular cells. 💡 bit.ly/46LuKOe

Scientists with Drs. Mano and Silva showcase the development of injectable human protein-derived cell carrier microgels. Microgels sustain cell viability by providing an environment of growth factors while promoting the outward migration of MSCs. 💡 bit.ly/4lmFxCY

Dr. @Didem_Karakas and a team in Dr. Bulent Ozpolat's lab at @MDAndersonNews found that the expression of eEF2K is associated with shorter patient survival and that eEF2K signaling is critical for the #PDAC tumor growth. go.nature.com/4lKudQT

In this @NatureComms paper, Dr. Guolei Zhao and a team in Dr. Teresa O’Meara's lab at @UMMicroImmuno highlight the critical role of Als4112 in Candida auris colonization and virulence. 📝 go.nature.com/4exrfgh

Lars Kemp (@kemp_lars) and a team in the @GloerichLab analyzed gastric tumors to identify the molecular changes that contribute to the progression of indolent to aggressive diffuse-type #GastricCancer legions. 🔖 @Gut_BMJ: bit.ly/44SiD0r

Researchers in the @IsaacLeeLab identified two distinct but interconnected ALK7-driven non-canonical pathways that promote #PDAC dissemination. Check out their paper: bit.ly/402v86X

C. auris conserved adhesin is required for skin colonization via #keratinocyte attachment and direct interactions with host #ECM proteins, especially basement membrane proteins such as laminin. 🔬 Learn more from Dr. Teresa O’Meara and colleagues. 🫶 👉 go.nature.com/4exrfgh

Scientists discover how #PDAC cells survive gemcitabine combined with Nab-paclitaxel neoadjuvant therapy and attenuate immune response caused by pyroptosis. CircERC1 facilitates chemoresistance through inhibiting pyroptosis and ECM remodeling. 🔗 bit.ly/4eynLdv

New #review in @jclinicalinvest! 🤓 Dr. Shengxi Wu and colleagues uncover a key role of retinoic acid signaling in neuropathic pain and associated anxiodepression via regulation of #ECM homeostasis. 👇 Give it a read: bit.ly/45Sbezd

T16 has demonstrated potential for regulating #ECM remodeling. 💭 M2 macrophages induced by T16 significantly enhance the activation of transforming growth factor beta-1. 👉 Read the study here: bit.ly/3ZS5oKo

Dr. Ye Zhao and colleagues demonstrate that the integration of CAFs into an #OvarianCancer organoid culture model results in the promotion of tumor growth and the mediation of resistance through multiple signaling pathways. bit.ly/3ZVZ9p0

This work presents a comprehensive proteomic analysis of the liver #ExtracellularMatrix across different age stages, uncovering significant age-related changes. 🤩 Check it out: bit.ly/4etnOao

The authors examined human dermal fibroblasts (HDFs) from aged skin and observe that they produce lower extracellular #fibronectin densities in vitro than young HDFs. bit.ly/3TcE5Xu

Interested in extracellular matrix dynamics in tumor #immunoregulation? In this #review, the authors discuss the topic with a particular focus on how key ECM components contribute to immune modulation. 🔗 bit.ly/4ehCERl