Yoshimi Lab (NCC Official Account)
@YoshimiLab
Studying aberrant splicing in cancer @NccriOfficial /Long-read/Omics/mRNA vaccine/ASO/Spatial/国立がん研究センター研究所 がんRNA研究分野/PI: @AkihideYoshimi /東大・慶應・東京科学大・北里大 連携大学院
千葉大学 北本匠先生のグループとの共同研究がDiabetesに掲載されました！おめでとうございます㊗️ Our collaborative research with Dr. Takumi Kitamoto’s group at Chiba University has been published in Diabetes! 🎉 diabetesjournals.org/diabetes/artic…
【第84回日本癌学会学術総会📚大会紹介📚No.1】 第84回日本癌学会学術総会、学術会長の大島正伸先生（金沢大学がん進展制御研究所）に大会開催に向けてコメントを頂きました！ #JCA84 #癌学会 #金沢
横浜市立大学國本先生らとの共同研究の成果がHemaSphereに掲載されました！ Our collaborative research with Dr. Kunimoto and colleagues at Yokohama City University has been published in HemaSphere!” onlinelibrary.wiley.com/doi/10.1002/he…
The ASIA RNA Club (Japan, Korea, China, Taiwan, Singapore, Australia), which used to be held online, is pleased to announce its 1st in-person meeting! Please join us in Seoul, Korea (Nov. 3 to 5), with Dr. Narry Kim of SNU as the main organizer! #ASIA_RNA asiarnaclub.org
Journal Club-89 @Cancer_Cell IIntravesical BCG administration for bladder cancer led to the accumulation of monocytes, neutrophils, and dendritic cells at the tumor site, promoting CD8⁺ T cell activation through enhanced antigen presentation. Notably, BCG stimulation also…
Journal Club-89 @Cancer_Cell 膀胱がんへのBCG投与により、腫瘍局所では単球・好中球・樹状細胞が集積し、高い抗原提示能を介してCD8⁺…
僕が学生の頃は欧米まで出かけないとなかなか分野の最先端を走る研究者との交流ができなかった気がするのですが、最近は、近隣各国の研究室から、おっ！これは美しい！という仕事が出てくるのを頻繁に目にするようになりました。国内の研究集会では決して味わえない交流の良いチャンス！ #ASIA_RNA
吉田澪奈さんが第26回日本RNA学会で口演しました！ Mina Yoshida gave an oral talk at the RNA2025 @RNA_Japan in Sendai‼️ "Multi-omics Profiling of Splicing Regulation and Mechanism-based Design of Splicing-modulating Antisense Oligonucleotides"
Journal Club-88 @ScienceMagazine A targeted LNP platform was developed to preferentially induce CD19-CAR expression in CD8⁺ T cells in vivo. High-efficiency CAR expression in CD8⁺ T cells was confirmed through the in vivo gene delivery. Moreover, broad and transient B cell…
Journal Club-88 @ScienceMagazine 標的指向性LNPにより、in vivoでCD8+ T細胞にCD19-CARを選択的に発現させる手法が開発された。In vivoでの遺伝子導入で高効率にCD8+ T細胞のCAR発現が確認され、さらに脾臓やリンパ節も含めた広範な一過性のB細胞除去（immune…
Journal Club-87 @CellCellPress This study reveals that m6A modifications on mRNA can promote mRNA decay by reducing translation efficiency, while mcm5s2U modifications on tRNA alleviate this effect. Together, they form a novel translation-dependent decay mechanism that plays a…
Journal Club-86 @Nature RARE-seq: a novel #cfRNA profiling method targeting Rare Abundance Genes (RAGs) + correcting for platelet-derived noise. More sensitive/specific than RNA-seq. 🌟Applications: early cancer detection, drug resistance, tissue injury, RNA vaccine tracking, and…
Journal Club-86 @Nature cfRNAの新たな解析手法「RARE-seq」。 Rare Abundance Genes (RAG) を標的としたターゲットパネルの設計と、血小板由来の cfRNA による影響の補正を通じて、RNA-seqより高感度かつ高特異性な cfRNA…
吉見昭秀さんが第41回日本DDS学会学術集会で招待講演しました。 「特別企画1 革新的DDS製剤開発に向けての取組および協業」 東京科学大学 西山伸宏先生とともに登壇です。 @AkihideYoshimi gave an invited talk at the 41st Annual Meeting of the Japan Society of Drug Delivery System.
#JSPS Postdoctoral Fellowship (2y) call is now open! Our lab is happy to host and support the candidates from the application stage. Feel free to reach out! #postdoc jsps.go.jp/english/e-fell…
Looking for an opportunity to conduct collaborative research in Japan? Application Guidelines for JSPS International Fellowship Programs are now available on our website. The call for application is to be open in late June. Check out the links below and consider applying!
Journal Club-85 @CellCellPress 本研究はSRSF2・ZRSR2変異をもつMDS/AMLで生じるミススプライシングを解析し、CLK3とRHOT2 由来のペプチドが…
Journal Club-85 @CellCellPress Mis-splicing in SRSF2/ZRSR2-mutant MDS/AML generates frame-shifted peptides from CLK3 and RHOT2 that presented by HLA-A*02:01 as “public” neoantigens. Patients’ T cells reactive these peptides are functionally impaired with reduced NF-κB signaling,…
Mina Yoshida presented a poster at #RNA25 meeting of the @RNASociety in San Diego. 吉田澪奈さんがThe 30th Annual Meeting of the RNA Society in San Diegoでposter発表をしました。
Journal Club-84 @MolecularCell 240種類以上の転写因子(TF)のisoform 約700種類を対象にisoforms間で網羅的解析を行い、TF isoformsがもたらす分子作用の多様化を明らかにした。加えて、TFの持つ主要ドメイン以外の領域で、柔軟な構造をとるIDR (intrinsically disordered…