Joshua Mendell
@Mendell_lab
Scientist in the Department of Molecular Biology at UTSW/HHMI. We study post-transcriptional gene regulation & noncoding RNAs in normal physiology and disease.
Amazing work from @chivukula_raghu on how a repeat expansion causes disease by impairing tRNA splicing👇. This is very important work that illuminates how polyGlycine repeats cause neurodegeneration, similar to mutations in tRNA splicing factors. Congrats Raghu and team!
Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗 science.org/doi/10.1126/sc…
Principal Investigator Joshua Mendell (@Mendell_lab) and researchers at @UTSWMedCenter highlight the functional versatility of snoRNA sequences and expand the known mechanisms through which noncoding RNAs orchestrate ribosome biogenesis. cell.com/molecular-cell…
Beautiful work with translational potential. Congrats Igor and team! (and thanks for providing something positive on this platform!)
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵biorxiv.org/content/early/…
It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. I am happy to re-post this thread about our pre-print that is now published in @MolecularCell. authors.elsevier.com/sd/article/S10…
I’m excited to share a pre-print from our lab describing how an ultraconserved long noncoding RNA functions as a unique ribosome assembly factor. This work was led by the talented postdoc Jong-Sun Lee (not on X). Here's a brief 🧵 with the key findings 1/-biorxiv.org/content/10.110…
Very exciting story from @ScientistJoanna @RuggeroDavide and colleagues! Great example of the importance of translational control in cancer and a very cool mechanism.
We are excited to share our new work out today in @NatureCellBio uncovering a new Achilles heel of pancreatic cancer. Myc is a key driver of PDAC and predicts poor survival. Thus, we asked the question of how Myc protein levels are regulated in PDAC. 👉 rdcu.be/d8xLT 🎉
Hello Twitter friends! For those of you making the leap to the other place 🦋 please find me at: mendell-lab.bsky.social Looking forward to seeing you there!
HHMI Investigator Joshua Mendell (@Mendell_lab) at @UTSWMedCenter helped discover that tRNAs play a role in stabilizing or degrading some mRNAs during translation. Their findings could one day help tailor vaccines and disease therapies. Learn more: hhmi.news/4hZMqJa 👈
I’m thrilled to share this story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. science.org/doi/10.1126/sc…