Xin Gu
@XinGu0317
Assistant professor @DFCI_CancerBio and @HarvardCellBio; Previous Postdoc fellow @HMS_Neuro; Previous PhD student @MITBiology
I'm thrilled to join @DFCI_CancerBio and @HarvardCellBio as a tenure track assistant professor Sept 2024! The Gu lab elucidates mechanisms underlying cellular homeostasis, with our initial effort on nuclear protein turnover by the ubiquitin-independent midnolin-proteasome pathway
Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗 science.org/doi/10.1126/sc…
Great study from @ChrisNardone95 from @RapoportLab on organelle pH regulation! He characterized a super cool complex that assembles v-ATPase. Congratulations 🎊🍾🥳
Excited to share my first post-doc paper! Here, we make headway in understanding how metazoans regulate the pH of their organelles. Turns out, there exists a heterotrimeric complex required for V-ATPase assembly. We delve into the mechanism of this chaperone. Stay tuned for more!
New online! A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients bit.ly/3GjrXRN
Super grateful for the generous support from Esther A. & Joseph Klingenstein Fund! We are excited to make more discoveries uncovering the roles of the midnolin-proteasome pathway in neurons!
Congratulations Xin Gu, Ph.D., recipient of a Klingenstein Fellowship Award in Neuroscience for the project, "Elucidating the Role of the Midnolin-Proteasome Pathway in the Central Nervous System." @XinGu0317 xingulab.dana-farber.org
A new study in @CellPressNews led by @DanaFarber’s @XinGu0317 highlights midnolin as a key regulatory component of proteostasis in plasma cells and suggests that restoring or enhancing this pathway could represent a novel therapeutic avenue in myeloma treatment. Read more:…
So happy and proud to see our story online!! Thank you, the midnolin team!
Online Now: Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma dlvr.it/TLPfxk
Thank you @DamonRunyon for the generous support! Very excited to be one of this year’s Dale F Frey Award for Breakthrough Scientists!
@XinGu0317 is investigating a newly discovered pathway that helps degrade key proteins involved in cancer, including several linked to blood cancers, in order to inform the development of new treatments.
While working on midnolin, the @sshaolab serendipitously solved a beautiful high-resolution structure of TXNL1 bound to the proteasome. We also show that oxidative stress caused by certain metal/metalloids leads to TXNL1 ubiquitin-independent degradation. biorxiv.org/content/10.110…
Seeing is believing! Our sequel now shows precisely how midnolin delivers substrates directly to the proteasome by repurposing established proteasomal subunits, a process critical to suppress multiple myeloma via IRF4 degradation. biorxiv.org/content/10.110…
In this week’s @Nature, we report that nutrients do not activate mTORC1 through degradation of GATOR1 component DEPDC5. Other molecular events signal the presence of amino acids to this essential growth pathway! nature.com/articles/s4158…
Out in @PNASNews now, we find that the Rag-Ragulator heptamer anchors the GATOR supercomplex to the lysosome. Our results highlight the complex role the Rags play in regulating mTORC1 activation and lysosomal homeostasis (1/2)
I am excited to share our preprint: “A torpor-like state in mice (TLS) slows blood epigenetic aging and prolongs healthspan”. Congratulations to @LornaLJayne and big thanks to our collaborators @prof_horvath, @bloodgenes, @VadimGladyshev and others. biorxiv.org/content/10.110…