Siniša Hrvatin
@hrvatin_sinisa
Whitehead Institute and Department of Biology, MIT. Biology of torpor and hibernation. Neuroscience, cellular adaptations, applications.
Our story “A torpor-like state in mice (TLS) slows blood epigenetic aging and prolongs healthspan” is now out: nature.com/articles/s4358… Big congrats to @LornaLJayne, Aurora Lavin-Peter, and Julian Roessler, and thanks to @prof_horvath, @bloodgenes, @VadimGladyshev, and others.
I am very excited to share our story on genetic mechanisms of cellular cold tolerance. Congratulations to Breanna Lam, Kat Kajderowicz @katclone, and collaborators @HeatherKPhD @genfren @MohamedBrolosy @JswLab biorxiv.org/content/10.110…
I am excited to share our preprint: “A torpor-like state in mice (TLS) slows blood epigenetic aging and prolongs healthspan”. Congratulations to @LornaLJayne and big thanks to our collaborators @prof_horvath, @bloodgenes, @VadimGladyshev and others. biorxiv.org/content/10.110…
We are recruiting a technician! Our lab studies the biology + applications of hibernation-like states with focus on neuroscience. Position is ideal for college grads interested in working largely independently for two years ahead of pursuing a PhD or MD. wibr.wd1.myworkdayjobs.com/en-US/WIBR-Car…
We updated our database and now list 385 postdoc fellowship opportunities (w/ description, deadline, amount, eligibility, etc). Getting one means a lot more freedom to do the work you want to do.
Understanding and engineering thermotolerance in plants could have tremendous beneficial effects. Beautiful work! science.org/doi/10.1126/sc…
Surprising observation that human brain temperature is ~38.5C (higher than core body temperature). Feature? academic.oup.com/brain/advance-…
Not too long ago, this would take 10,000 experiments that could not be coherently integrated. What a landmark study with the largest and richest single dataset of cell function to reference, mine, build deep learning models on. Bravo colleagues @josephmreplogle @JswLab
Our genome-scale Perturb-seq paper is out today in Cell! cell.com/cell/fulltext/… @CellCellPress @JswLab Thanks to all the authors and reviewers for their contributions. See the thread below for key findings.
Hibernating animals tend to live longer. Why that is, we don’t know. Exciting results in marmots suggest that epigenetic aging slows down during seasonal hibernation. biorxiv.org/content/10.110…
Beautiful study in the same issue @nature describing the effects of stimulating neurons and inducing a torpor-like or hibernation-like state. nature.com/articles/s4158…
Excited to share our first paper on torpor. Big thanks to @SenmiaoS and all our collaborators! nature.com/articles/s4158…