Min WU
@WUMIN_LAB
membrane dynamics | pattern formation | cell size | lab @YaleCellBio🌎 | @MBIsg PI alumni 🌏 https://bsky.app/profile/wumin-lab.bsky.social
I'm prototyping a little tool for interactively visualizing the near-nearest neighbor network in single-cell RNA-seq. Clicking a cell triggers a wave, revealing its nearest neighbors, then their neighbors, and so forth. Data: 10k PBMCs from a Healthy Donor (v3), 10x Genomics
(some) academics have hated him for political & personal reasons but-- frankly--I have not followed that debate. sneering opinions about a Harvard professor by a professor elsewhere should be examined closely. my neuroscientist husband was on one side or another of this debate,…
No. I know you won’t believe me, so here is @paulkrugman on Gould:
fascinating
A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites biorxiv.org/content/10.110… #biorxiv_cellbio
Realized this morning that my submission got selected @YaleMed Beauty in Science 2025 exhibition! Seeing the live-assembly of filopodia projections by formin mDia3 in mast cells got me really stoked back then! #FluorescenceFriday
(not to complain about Bluesky where you are made uneasy hearing your own voice echo in the sepulchral quiet of an upscale suburban mall that closes early.)
A live-cell biosensor of in vivo receptor tyrosine kinase activity reveals feedback regulation of a developmental gradient dlvr.it/TLfp6Q
Joe Tyler @jtyler91, Anthony Davidson, Vassilis Koronakis & team find that inhibition of PAK activity leads to the production of PI(3,4,5)P3 at the plasma membrane & a dysregulation of the actin cytoskeleton. journals.biologists.com/jcs/article/13… Article: journals.biologists.com/jcs/article/13… #OpenAccess
My lab was totally destroyed tonight by an Iranian missile. Nobody was hurt. Flies, plasmids, cells, equipment - all gone. Heart breaking. If during the course of the past 16 years, you have received something from my lab - please keep them safe.
JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux biorxiv.org/content/10.110… #biorxiv_cellbio
Remember to adjust for multiple comparisons when searching for memory-encoding neuronal regulation! nature.com/articles/s4158…
Procrastination with two pending grant deadlines 🤭
In case people don’t know: International students are separately admitted with much higher criteria than for domestic applicants at Harvard. It was a brilliant strategy for the U.S. to get the smartest people in the world.
BREAKING: At the Harvard Graduation Ceremony moments ago, Harvard President Alan M. Garber just got a standing ovation after taking a subtle shot at President Trump. "To the class of 2025, from down the street, across the country and around the world. AROUND THE WORLD! JUST AS…
Dictyostelium on the cover! Pattern formation along signaling gradients driven by active droplet behavior of cell swarms | PNAS pnas.org/doi/10.1073/pn…
too bad that Stephen Jay Gould was never awarded a (much-deserved) Pulitzer prize. three of us, Pulitzer jurors in non-fiction for that year, had chosen "Wonderful Life" to win; but the board overruled us. see online: "Stephen Jay Gould was a finalist for the 1991 Pulitzer Prize…
Deep Time and Ceaseless Motion by Stephen Jay Gould This month, 45 years ago, Mount St. Helens erupted. Gould, author of Ever Since Darwin and Wonderful Life, flew over a year later and wrote this piece about the crucial lessons of geology: nybooks.com/articles/1981/… via @nybooks
My two NIH cancer research grants were terminated today. One involving breast cancer prevention is an “outstanding investigator award” and had received a perfect score by reviewers. How does ending lifesaving cancer research make Americans healthier? @harvardmed @aacr
Majority of data never get the opportunity to be published. This is F-actin clearly organized in two modes, clusters or meshes, possibly mediated by formins and Arp2/3.
A number of people have asked me why we titled our recent paper "On the Biology of a Large Language Model". Why call it "biology"?
Excited to see this paper out in the themed collection "Soft Matter Pioneering Investigators": pubs.rsc.org/en/content/art… Grateful for my advisor Andrej Košmrlj for his help, as well as @KayTrue for patiently teaching us about membranes!
Just posted our work on pattern formation of lipid domains in membranes! Motivated by some beautiful experiments, we discussed how a combination of phase separation and elastic deformation leads to patterns in an asymmetric membrane. Suggestions welcome!! arxiv.org/abs/2309.05160