石黑大雄
@ppa007hot
只要活着，就会遇见好事情。
We introduce a new tool to study F-actin remodeling, ADPact, a peptide sensor of ADP-actin. Unlike Lifeact and Phalloidin, which bind both ATP- and ADP-actin, ADPact only detects ADP-actin. It neither overlaps with cofilin nor affects treadmilling 🙌🤗. pnas.org/doi/10.1073/pn…
Majority of data never get the opportunity to be published. This is F-actin clearly organized in two modes, clusters or meshes, possibly mediated by formins and Arp2/3.
A hollow TFG condensate spatially compartmentalizes the early secretory pathway nature.com/articles/s4146…
There are so many weird Biology quirks that I somehow missed before and am only just finding now... Apparently translation can and *does* initiate from EVERY codon With the caveat that any codon other than the canonical AUG / GUG / UUG options induce transcription at such…
Live-cell quantification reveals viscoelastic regulation of synapsin condensates by α-synuclein | Science Advances science.org/doi/10.1126/sc…
Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ @jpkreysing, Johannes Betz,Turoňová lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp 🔗 Preprint here: doi.org/10.1101/2025.0…
MINFLUX works well in theory, but system and sample imperfections can lead to suboptimal resolution. To address this, @JonasRies and I developed SimuFLUX: biorxiv.org/content/10.110…, a realistic simulator to optimize MINFLUX experiments before samples go on the microscope.
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry: Cell cell.com/cell/fulltext/…
4Pi-SMS and pan-ExM reveal, in a close collaboration with the Rothman lab, a surprising tetraplex organization and self-assembly of rim golgins, which we believe can explain stack formation of the Golgi apparatus: biorxiv.org/content/10.110…
写了一篇很长的DeepSeek R1科普文，从AlphaGo战胜李世石出发，到ChatGPT类模型的训练困境，和我看到DeepSeek R1真正的闪光点，一路贯穿下来竟然写的心潮澎湃。 特别是在OpenAI和Claude的各种操作和言论后，让我更想把R1-Zero对人类的贡献告诉给更多不懂AI的人。 mazzzystar.com/2025/01/30/cha…
Very excited to share my work from the Bogan lab on a novel regulatory mechanism in the early secretory pathway. Lots of surprising findings as we undertook the journey on the fascinating TUG protein which will be elaborated in a thread to follow soon. biorxiv.org/content/10.110…
Excited to share my first preprint in @XiaoyuShi2 lab! A 3D stack ExM image of cell is attached here to share you with my daily observation (magenta: whole lipid, cyan: whole protein). I believe every tiny structure has a story. And this time it is about the nuclear invagination.
Check out our surprising finding in nuclear invagination's function: regulating ribosome biogenesis. Nuclear tunnels = more ribosomes! I am proud of my talented student @YinyinZhuang, and inspiring collaborators @wtzhaolab, @ChrisEMiles, and @razorenovalab!
一位朋友做了一件我特别想做、但实在是懒得去做的事儿：在日本这个自由的社会，创立一家简体中文出版社，把国内有思想的简体中文作者无法出版、或者只能阉割出版的书原样印出来。 目前已经出版了3个品种，书都是放在内山书店、东方书店、光和书房、单向街书店、大阪知非书店以及亚马逊销售。…