Lisandro H. Otero
@LisandroHOtero1
Microbiologist. PhD in Biological Sciences. Expertise in Structural Biology of macromolecules using X-ray Crystallography and Cryo-EM. Fanático CABJ.
Sometimes one is so lucky to work with such talented people. And the results are magnificent! Very happy to see that our paper is out today in @ScienceAdvances A big step forward in our knowledge on the light-driven signaling mechanisms in phytochromes. science.org/doi/10.1126/sc…
📣El grupo de Fotobiología y Optogenética, dirigido por la Dra. Jimena Rinaldi, incorpora a postulantes a beca doctoral CONICET para estudiar las Bases moleculares del sensado de luz y sus aplicaciones biotecnológicas
High-resolution cryo-EM structures of small protein-ligand complexes near the theoretical size limit biorxiv.org/content/10.110… #biorxiv_biophys
Time-resolved cryo-electron microscopy can resolve protein motion on millisecond or even microsecond timescales, but the need for highly specialized tools and skills limits the method’s reach nature.com/articles/d4158…
Delighted to share that our cryo-EM work with @inmunova on engineered immunogens capable of eliciting neutralizing antibodies against hemolytic uremic syndrome is featured on the cover of Protein Science! 🔗 doi.org/10.1002/pro.70…
The ChimeraX 1.10 release candidate and daily builds can predict small complexes of proteins, nucleic acids and small molecules using Boltz on your Mac, Windows or Linux computer. rbvi.ucsf.edu/chimerax/data/…
A historic milestone at @Exactas_UNRC : our first-ever #SAXS data collection of a protein! Deep thanks to @DiegoLamas1 and @fernandezma92 for their outstanding dedication. This technology now complements our #EM facility, further empowering structural biology at UNRC.
Muy felices por este hermoso trabajo recientemente aceptado en el Chemistry, CEJ. Seremos tapa! Gran trabajo en equipo con colegas estupendos de la UNRC y del INIFTA. Seguimos haciendo Ciencia de Calidad. …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch… @cihidecar @umymfor @NMarianoCorrea @RAICYT_Ar
Luis Leloir discovered a completely new class of biological compounds – sugar nucleotides – and showed that they are fundamental to the metabolism of carbohydrates. He was awarded the 1970 Nobel Prize in Chemistry.
Machine learning accelerates docking screens of multi-billion-scale chemical libraries Chemists and biologists have long been fascinated by the enormous landscape of possible drug-like molecules, yet experimentally testing even a fraction of these remains daunting. Recent…
Científica de Alemania y estudiante de Italia visitan Exactas en el marco del Programa Erasmus+ exa.unrc.edu.ar/cientifica-de-…
Happy to share the floor with @davidroper2 and Shahriar to explain a bit of the complexity and implications of the fascinating peptidoglycan field....thanks @ProteinSociety for the initiative
Let's go! 🤩📚 @ProteinSociety @davidroper2 @JHermoso_CSIC Shahriar Mobashery #bacterialcellwall #cellwall
Que lo construido en estas casi siete décadas de historia siga siendo el sostén y la guía para desarrollar nuevos conocimientos.
Congratulations to our scientists from the García Alai Team for their new paper presenting the yerba mate genome! 🧉🧬🧪
Scientists at @Exactas_UBA, @EMBLHamburg, @MCB_Illinois and others mapped yerba mate’s genome, providing surprising facts about its biochemistry and evolution of caffeine biosynthesis. Find out more: embl.org/news/science-t…
🚨Preprint Alert!🚨 #ProteinDesign is advancing rapidly—wouldn't it be great to seamlessly combine design tools to achieve more than what each can do alone?🤔 Here, we introduce AI.zymes: A modular platform for evolutionary #EnzymeDesign.♻️🖥️ biorxiv.org/content/10.110… 1/🧵
What is needed to accelerate enzyme engineering using machine learning? #Data We develop a ML-guided platform that integrates DNA assembly, gene expression, and functional assays. ML models predict improved variants. @akarimlab @NUSynBio @NatureComms nature.com/articles/s4146…
Kexin Zhang et al.: A new statistical metric for robust target detection in cryo-EM using 2D template matching #3DReconstructionAndImageProcessing #SingleParticleCryoEM #Imaging @umassboston... #IUCr journals.iucr.org/paper?S2052252…
Another successful cryoEM data collection at @NanotecLNNano. Thanks @CNPEM for providing us with the opportunity to advance our structural biology projects from Argentina. Muito obrigado! 🇦🇷🤜🤛🇧🇷
De novo design of anti-venoms! nature.com/articles/s4158… @UWproteindesign I highly recommend this book to anyone interested in the biochemistry of venoms: amazon.com/Venomous-Deadl…