Assoc. Prof. Tim Sargeant

I had the pleasure of talking to Dr @normanswan on the ABC about our work on #autophagy - how it slows biological #ageing (#aging) and what we're doing at @sahmriAU to be able to measure this process in you. Ageing, and how cells do a clean up abc.net.au/radionational/…

The Autophagosomes & Endolysosomes meeting wraps today in Whistler, capping days of deep insight into lysosomal biology & autophagy. 👏 Congrats to our Keystone scholarship awardees—your future in science is bright! 🔗 keysym.us/scholarshipssms #KSAutophagy25 @bealelab

Well done @SanjyySingh for receiving important recognition for your work on #autophagy at the recent Keystone Symposium in Canada

In a recent study published by our group, we measured autophagic flux in human PBMCs. We cannot yet measure #autophagy in organs, which is why we are developing tissue specific autophagy biomarkers.

New research paper on human #autophagy from our group at @sahmriAU. Dr Linh Dang analysed autophagic flux with cell type specificity. We show data important for designing clinical trials for human autophagy - cell type matters: faseb.onlinelibrary.wiley.com/doi/10.1096/fj… #aging

Our paper about how autophagy changes in mice as they age is now available at @PLOSONE ! Big thanks to @TimSargeant1 , @turnerMNDlab & team, as well as @sahmriAU , @uniofadelaide & @hosp_research ! journals.plos.org/plosone/articl…

Sunrise from @sahmriAU with the Adelaide Oval and St Peter's Cathedral

A/Prof @TimSargeant1 is the latest guest to feature on the Community Conversations podcast. 🎙️ A/Prof Sargeant discusses all things autophagy - the latest research, tips for optimising cellular health and more! Listen 🎧 sahmri.au/CC-Tim-Sargeant

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: isa11.org Join us for five inspiring days of cutting-edge autophagy research!

I'm looking forward to attending the 11th International Symposium on #Autophagy. The last one in Sapporo, Japan was a great meeting and that is set to continue in Lorne, Victoria, in November of this year. Early bird rego closes August 29 here: isa11.org #isa11

Crucial new pilot study to investigate whether #rapamycin can be used against dementia causing diseases published yesterday. nature.com/articles/s4385…

NEW STUDY: It's dogma that fasting is good for you because it increases autophagy, the recycling of cell parts. But in the largest study ever, 6 months of time-restricted eating (TRE) or calorie restriction (CR) did not increase autophagy Huh? Is fasting still worth it? ... 🧵

New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the largest human autophagy study to date. Although significant, changes in autophagy were modest. #autophagy #fasting #aging @sahmriAU physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Beyond the Hallmarks: What are we missing in ageing research? At the Global Conference on Gerophysics 2025, I posed several uncomfortable—but necessary—questions: 🔹 Why haven't we don better than caloric restriction for lifespan extension in mammals—after 50 years? 🔹 Have…

We can't work out why funds designated to medical research can't be released from the MRFF. Not new debt, current funds. So we animated it 👇. Share this, tag in your MPs, and help AAMRI secure the election promise that the unspent funds, that are allocated and available, will be…

In our recent @NatureCellBio comment, we highlight mounting evidence that —contrary to dogma— #autophagy doesn’t always decline with age.. in fact, it often increases! @SanjyySingh @TimSargeant1 @sahmriAU @hosp_research nature.com/articles/s4155…

Does autophagy really decline with ageing? What can LC3-based measurements truly tell us about autophagy? And how can we bridge the gap between preclinical findings and human biology? We explore these questions in our latest comment in @NatureCellBio: bit.ly/4cjOSHU

Check out our latest Comment in @NatureCellBio on #autophagy (how cells of your body recycle damaged material). While declining autophagy is often seen as a hallmark of #ageing, we explore emerging exceptions to this idea. @sahmriAU @UniofAdelaide nature.com/articles/s4155…

Meet Romulus and Remus—the first animals ever resurrected from extinction. The dire wolf, lost to history over 10,000 years ago, has returned. Reborn on October 1, 2024, these remarkable pups were brought back to life using ancient DNA extracted from fossilized remains. Watch…

I've dreamed of this since Jurassic Park came out

"Just as physical exercise stresses the body to build stronger muscles, a controlled mild stress to #lysosomes could boost resilience and improve health outcomes across the #lifespan." nature.com/articles/s4155…