Tanner Wiegand

New pre-print(s) from the Sternberg Lab in collaboration with @LeifuChangLab! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: tinyurl.com/mr3fd493

Our story on RNA-templated gene synthesis in antiviral immunity is out today in @ScienceMagazine! We discovered a cryptic gene, neo, that is created de novo by infected cells in a remarkable feat of molecular gymnastics🤸 science.org/doi/10.1126/sc…

Congratulations to @shsternberg on this recognition for the incredible science coming out of your lab! So glad to be part of your team, and excited for many cool new findings to come!

Check out the latest story from the Sternberg group: phages coopted transposon-encoded nucleases (TnpB) and repurposed them for regulation of host genes! nature.com/articles/s4158… Thrilled to see this work in print, & a huge thanks to my amazing co-authors!!

In a new preprint from the lab, @stephentang23 et al uncover a remarkable mechanism of antiviral immunity mediated by bacterial reverse transcriptase enzymes. Check out the thread below for more!

Ringing in the new year with a pre-print on the PARIS defense system! This work defines how viral proteins activate PARIS-mediated tRNA cleavage and how viral tRNAs rescue infection. tinyurl.com/5x7epzxd. Also check out complementary work from the Corbett lab!

New pre-print from the Sternberg Lab! Transposon-encoded nucleases (TnpB/IscB) gave rise to the CRISPR-associated proteins (Cas9 and Cas12), but were TnpB-like proteins domesticated for other functions? 𝙔𝙀𝙎!! doi.org/10.1101/2023.1…

We’re beyond excited to share the newest pre-print from the Sternberg Lab! You thought all bacterial transposons (aka IS elements) were simple? Think again…🤓1/6

Ever wondered how do microbes control the activity of their #CRISPR adaptive immune systems? Check out our recent paper in Current Biology for some new insights!

Excited to share our new paper! We repurposed the signaling pathway of type-III CRISPR systems to detect SARS-CoV-2! This system could be re-programmed to detect other host, bacterial, or viral RNAs. cell.com/cell-reports-m… Graphical abstract and thread below!

A HUGE Congratulations to @LainaHall and Pushya Krishna who both received the prestigious #GoldwaterScholarship today!! It's been such a treat to work with these two exceptional undergrads!

Excited about our new paper in @CellReports detailing SARS-CoV-2 genomic surveillance in Bozeman, MT and the identification of ORF7a truncation mutants! doi.org/10.1016/j.celr… @WiedenheftLab @MSU_MicroImmuno #Science #COVIDー19

We continue to share research highlights from the past year which inevitably include #COVID19 as part of our journey of trying to manage the pandemic, both professionally and personally. Read the report from @artemnemudryi @WiedenheftLab et al. that @CuriousDrKris picked for us.

Congratulations to the four #MontanaState students who have been named Goldwater scholars — Laina Hall, Pushya Krishna, Elliott Pryor and Matthew Thompson — the nation's premier scholarship for undergraduates in STEM fields. montana.edu/news/21004

Merry Christmas, fellow phage hunters!🎄❄️🎅🏽🦠

Newly acquired I-F CRISPR spacers reproducibly originate from specific regions of plasmids, and Cas1-2/3 proteins are sufficient for naive adaptation. Read about it in the @CRISPRjournal! doi.org/10.1089/crispr… #MontanaState #CRISPR

Type III #CRISPR signaling cascade repurposed to be a #SARSCoV2 viral diagnostic! Check out our pre-print, "Intrinsic Signal Amplification by Type-III CRISPR-Cas Systems Provides a Sequence-Specific Viral Diagnostic" medrxiv.org/content/10.110… Thanks to all co-authors! #MontanaState

The sky ablaze, a deftly painted morning portrait

And in between We draw a line But we can't see Where it's been

If only Bradley's arm was longer. Best photo ever. #oscars