Tanner Wiegand
@TannerWiegand
Research scientist studying mobile genetic elements at Columbia University
New pre-print(s) from the Sternberg Lab in collaboration with @LeifuChangLab! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: tinyurl.com/mr3fd493
Our story on RNA-templated gene synthesis in antiviral immunity is out today in @ScienceMagazine! We discovered a cryptic gene, neo, that is created de novo by infected cells in a remarkable feat of molecular gymnastics🤸 science.org/doi/10.1126/sc…
Congratulations to @shsternberg on this recognition for the incredible science coming out of your lab! So glad to be part of your team, and excited for many cool new findings to come!
⭐️ Big news! HHMI is investing $300+ million in 26 new #HHMIInvestigators from 19 US institutions. These top scientists will drive groundbreaking research in diverse fields, from neuroscience to immunology to structural biology & beyond. Welcome to HHMI! hhmi.news/4df2eVs
Check out the latest story from the Sternberg group: phages coopted transposon-encoded nucleases (TnpB) and repurposed them for regulation of host genes! nature.com/articles/s4158… Thrilled to see this work in print, & a huge thanks to my amazing co-authors!!
In a new preprint from the lab, @stephentang23 et al uncover a remarkable mechanism of antiviral immunity mediated by bacterial reverse transcriptase enzymes. Check out the thread below for more!
I am delighted to share the newest work from the @SternbergLab, in which we discover RNA-templated gene creation as a mechanism of antiviral immunity. This is a story for anyone who loves molecular biology, and one that repeatedly left us in disbelief. doi.org/10.1101/2024.0…
Ringing in the new year with a pre-print on the PARIS defense system! This work defines how viral proteins activate PARIS-mediated tRNA cleavage and how viral tRNAs rescue infection. tinyurl.com/5x7epzxd. Also check out complementary work from the Corbett lab!
New pre-print from the Sternberg Lab! Transposon-encoded nucleases (TnpB/IscB) gave rise to the CRISPR-associated proteins (Cas9 and Cas12), but were TnpB-like proteins domesticated for other functions? 𝙔𝙀𝙎!! doi.org/10.1101/2023.1…
We’re beyond excited to share the newest pre-print from the Sternberg Lab! You thought all bacterial transposons (aka IS elements) were simple? Think again…🤓1/6
Ever wondered how do microbes control the activity of their #CRISPR adaptive immune systems? Check out our recent paper in Current Biology for some new insights!
Our pre-pandemic project is finally published! Here we shed light on how microbes regulate #CRISPR adaptation, the process of creating a molecular memory of a #phage infection. sciencedirect.com/science/articl…
Excited to share our new paper! We repurposed the signaling pathway of type-III CRISPR systems to detect SARS-CoV-2! This system could be re-programmed to detect other host, bacterial, or viral RNAs. cell.com/cell-reports-m… Graphical abstract and thread below!
A HUGE Congratulations to @LainaHall and Pushya Krishna who both received the prestigious #GoldwaterScholarship today!! It's been such a treat to work with these two exceptional undergrads!
Excited about our new paper in @CellReports detailing SARS-CoV-2 genomic surveillance in Bozeman, MT and the identification of ORF7a truncation mutants! doi.org/10.1016/j.celr… @WiedenheftLab @MSU_MicroImmuno #Science #COVIDー19
We continue to share research highlights from the past year which inevitably include #COVID19 as part of our journey of trying to manage the pandemic, both professionally and personally. Read the report from @artemnemudryi @WiedenheftLab et al. that @CuriousDrKris picked for us.
Congratulations to the four #MontanaState students who have been named Goldwater scholars — Laina Hall, Pushya Krishna, Elliott Pryor and Matthew Thompson — the nation's premier scholarship for undergraduates in STEM fields. montana.edu/news/21004
Newly acquired I-F CRISPR spacers reproducibly originate from specific regions of plasmids, and Cas1-2/3 proteins are sufficient for naive adaptation. Read about it in the @CRISPRjournal! doi.org/10.1089/crispr… #MontanaState #CRISPR
Type III #CRISPR signaling cascade repurposed to be a #SARSCoV2 viral diagnostic! Check out our pre-print, "Intrinsic Signal Amplification by Type-III CRISPR-Cas Systems Provides a Sequence-Specific Viral Diagnostic" medrxiv.org/content/10.110… Thanks to all co-authors! #MontanaState
And in between We draw a line But we can't see Where it's been
If only Bradley's arm was longer. Best photo ever. #oscars