Tom Snelling

Excited to share our preprint reporting on the discovery of a new ALPK1 variant causing ROSAH syndrome in a family with 7 affected members! We also characterise this variant, showing its constitutive activity in cells #ROSAH #ALPK1 #mrcppu #UoDLifeSciences biorxiv.org/content/10.110…

Available online - the Review "Diseases caused by altered specificity of a #proteinkinase for its allosteric activators" from Philip Cohen and @TWSnelling @mrcppu @dundeeuni. #AtypicalAlphaKinase #ALPK1 #ROSAHsyndrom #Spiradenoma authors.elsevier.com/sd/article/S09…

Quantitative Measurement of the Kinase Activity of Wildtype ALPK1 and Disease-Causing ALPK1 Mutants Using Cell-Free Radiometric Phosphorylation Assays: bio-protocol.org/en/bpdetail?id… Work by @TWSnelling at the @dundeeuni. #Reproducibility #LifeSciences #Biochemistry

Multimodal scanning of genetic variants with base and prime editing go.nature.com/3O6wQ0O

How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer? A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀 sciencedirect.com/science/articl…

Now open – a CRUK-funded PhD clinical research training fellowship in my team at the Wellcome Sanger Institute. crukcambridgecentre.org.uk/education-and-…

JOB ALERT! MND Accelerator Award funded postdoctoral position in my lab @mrcppu is now LIVE. We will use pooled CRISPR screening of iPSC motor neurons to identify new targets for ALS/MND. To learn more & apply: ppu.mrc.ac.uk/careers/recrui… Please help spread the word! Thank you.

Happy to share two protocols describing how to study #ALPK1 disease-causing variants using cell-based and cell-free kinase assays! They were used in our recent preprint on #ROSAH syndrome. (doi.org/10.1101/2024.0…) doi.org/10.21769/BioPr… doi.org/10.21769/BioPr… #UoDLifeSciences

Delighted to share our work in @NatureGenet using base editing to map genetic mechanisms of drug resistance. If you're interested in drug discovery then check it out. Access here rdcu.be/dXmlo [rdcu.be]. Congratulations to the team and @MatthewACoelho

Congrats to Celest Tay @taycell & Oliwia Mruk @olimruk who received Highly Commended Awards in the Life Science category of the Global @UndergradAward 2024. This was in recognition of their honours project research which both undertook @mrcppu buff.ly/4e8dIuI

Congratulations Elisha and Catriona: Professor Sir Philip Cohen's 50th and 51st PhD students awarded their degress ppu.mrc.ac.uk/news/elisha-an… @elishamccrory_ @catriona_aitken

An excellent postdoctoral opportunity to join @sapkota_mrcppu to work on WNT signalling and colorectal cancer. We are looking for someone with a with a strong background in cell and molecular biology. To apply: jobs.ac.uk/job/DGS778/pos… @mrcppu @UoDLifeSciences @dundeeuni

Congratulations to @TWSnelling and @OyieJessica for receiving International Sponsored Places to attend the Biomolecular Horizons Congress 2024! We can't wait to hear about their experiences at this global forum celebrating the latest developments in bioscience and biotechnology.

To restore cellular homeostasis, stress responses should be turned off at the right time and place. A paper @nature shows a ubiquitin-dependent mechanism through which unimported mitochondrial proteins silence the integrated stress response. nature.com/articles/s4158…

Thrilled to have been awarded the Howard Elder Prize for my work on ALPK1😃. This kinase is activated by bacterial ADP-heptose, but mutations that cause a genetic disease and a rare cancer allow it to also be activated by human metabolites! #ALPK1 @mrcppu @UoDLifeSciences

📢 Are you interested in joining our lab in Copenhagen🇩🇰 as a #postdoc? We are an ambitious and friendly research group 👩‍🔬👨‍🔬 working on the regulation of #metabolism and #inflammation by #ubiquitin 🔬🧬. Project details and application link below👇 Please share!

Thrilled to see this research published! ALPK1 is a kinase activated by bacterial ADP-heptose, but disease-causing mutations allow it to also be activated by human metabolites, thereby leading to chronic signalling! pnas.org/doi/10.1073/pn… #ALPK1 #ROSAH @mrcppu @UoDLifeSciences

Very happy to see my PhD work published 😊

Very excited to share my first preprint where I report advances in understanding how activation of ALPK1 by ADP-heptose triggers an immune signalling pathway coordinated by the E3 ligases TRAF6, c-IAP1 and LUBAC #ubiqitin #ALPK1 biorxiv.org/content/10.110… @mrcppu @UoDLifeSciences

Our updated #ubiquitin and #glycotime crossover paper is now online at @embojournal. Want to see what we have added since the @biorxivpreprint? Then head over there now and take a look! embopress.org/doi/full/10.15…