Svati Shah
@SvatiShah
Cardiologist studying genetics and metabolism
Congratulations @DrPRao! So well deserved!!
Huge s/o to the Gerszten lab (peer mentorship was invaluable!) and scientific advisory committee: @JenHoCardiology @SvatiShah @longlabstanford Dr. Benjamin Levine Excited to share more insights as this project develops!
Should there be systematic genetic screening for the most common variants of TTR amyloidosis? This piece explores the gaps & considerations of implementing V142I variant screening programs🧬 🔗bit.ly/4jf8T5D
📰A professional update 🔥 My recent boss, mentor, and friend @MkosiborodMD recently left @MidAmericaHeart and @saintlukeskc to lead late-stage CVRM development for @AstraZeneca. As a result, I am assuming a number of vacated leadership roles, including: Executive Director,…
CPET is essential for comprehensive care of patients w/ CHD, offering valuable prognostic insights & assisting in clinical decision-making across various congenital heart conditions, thereby significantly ⬆️patient management & outcomes. ✍🏼 @AdamPowellMD @_Dave_W @BarbaraCifra
1/ 🌟 New treatment paradigm in heart failure! The REMOTE-HF study explored BAY 2413555, a novel M2 receptor modulator aiming to enhance parasympathetic activity in HF patients. Findings show promise but come with some caveats nature.com/articles/s4159…
Fantastic talk from super ⭐️ @jregan2012 at @DukeMedSchool Precision Genomics Collaboratory retreat, 2nd place for best oral presentation! Metabolic pathways and snRNAseq for epicardial and pericoronary fat

Awesome talk from the incredible @drmrscoles at @DukeMedSchool genomics symposium. Cool work w/ a homegrown pipeline for WGS to identify causative genetic variants in families with arrhythmias. Sara is a rising ⭐️ in EP and arrhythmia genetics 🧬, keep an 👁️ out for her!

This @CellCellPress paper making the most of the #proteomics resource of the UK Biobank is a great Sunday read📖❗️ 🔗cell.com/cell/fulltext/… It highlights at scale the areas, where proteomics could provide meaningful insights: 🧵
Free nationwide genetic carrier screening of 10K reproductive couples during current or planned pregnancy offered during carrier screening for 1300 genes in Australia reported. 1 in 50 with a positive result & influenced pregnancy plans nejm.org/doi/full/10.10… @NEJM
Our 4th annual Genomics Scientific Retreat is only 3 weeks away! duke.is/PCG-retreat
SGLT2i demonstrate common (fatty acid) and distinct (ketogenic) metabolic signatures across the LVEF spectrum @senthil_selv @SvatiShah @MkosiborodMD @DukeHeartCenter @MidAmericaHeart @HFpEF @bborlaugmd ahajournals.org/doi/full/10.11…
Congratulations, great work @senthil_selv! A great step towards use of exogenous ketone therapy in HF
Our phase I study of 2 doses of exogenous ketones detailing PK and metabolic profiling in HFrEF by background SGLT2i Simpub #AHA24 & @JACCJournals #JACCBTS jacc.org/doi/10.1016/j.… 🙏 @SvatiShah @MarguliesLab @robmentz @FudimMarat and outstanding team @DukeHeartCenter @DukeMPI
#AHA24 Genomics and Precision Medicine Council @American_Heart on training in #CardioGenomics Thrilled to see major efforts in this direction @APLandstrom @AnwarChahal @rodendm @SvatiShah @iftikhar_kullo @MJAckermanMDPhD ahajournals.org/doi/abs/10.116…
Thank you @NatRevCardiol for sharing our vision for the future of #AHAFIT #ACCFIT training in #CardioGenomics recognizing the growing need for a #Cardiovascular #Genomics subspecialty #PrecisionMedicine @NLAWIL @WomenAs1 @CardioNerds @CardioSmart @KUCVM nature.com/articles/s4156…
Excited to be at #AHA24 and share the excellent work of our trainees, collaborators, and friends!
#AHA24 Early Career Spotlight on some amazing young and promising talent in the space of CV medicine. From Software to Hemodynamics, everything was represented. Thanks for AHA for funding this work. The future is bright. @AHAScience @AHAMeetings @emilyswlau @JessicaBlairB
Key programming for women in cardiology at #AHA24 Thanks to the developers and participants of these excellent sessions. @MonSangh @DrMarthaGulati @ErinMichos @Drroxmehran @JoChikweMD @SvatiShah @AHAScience @AnastasiaSMihai
Making you schedule for #AHA2024? Check out some of the professional development programming below!
NEW @AHAScience Scientific Statement from the Inaugural Primary Care Science Committee !! "Role of Primary Care in Achieving Life's Essential 8" @CircOutcomes Key takeaways ✅here: newsroom.heart.org/news/primary-c… Article 📰 here: ahajournals.org/doi/10.1161/HC…
New science advisory on Gene Therapy in CVD👇👇thanks to @P_StLaurent @yurikim_mdphd @APLandstrom @SvatiShah @Joseph_C_Wu and the fantastic Kricket Seidman
🆕AHA advisory published on Gene Therapy in Cardiovascular Disease. Education on genetic concepts, test results, & therapies to benefit patients & reduce the burden of CVD is critical. 📷 Delivery methods for gene therapy ✍🏼 @yurikim_mdphd @APLandstrom @SvatiShah @Joseph_C_Wu
Very excited to share our AHA Science Advisory where we discuss current promises and limitations of gene therapy in CVD. It was such an honor to work with @APLandstrom @SvatiShah @Joseph_C_Wu, Kricket, @AHAScience @American_Heart and @CircAHA @bwhcvls @BrighamWomens #GeneTherapy
CVD is the leading cause of 🌏 morbidity & mortality. Many are caused by damaging DNA 🧬 variants and require lifelong treatments that mitigate but do not cure disease. This advisory looks at gene therapies to treat CVD. ✍🏼: @yurikim_mdphd @APLandstrom @SvatiShah @Joseph_C_Wu
CVD is the leading cause of 🌏 morbidity & mortality. Many are caused by damaging DNA 🧬 variants and require lifelong treatments that mitigate but do not cure disease. This advisory looks at gene therapies to treat CVD. ✍🏼: @yurikim_mdphd @APLandstrom @SvatiShah @Joseph_C_Wu