Lab of Dr. Nephi Stella, University of Washington
@StellaLab11
The lab of Dr. Nephi Stella studies the molecular mechanism and therapeutic value of cannabinoid-based molecules.
The 2025 GRC on Cannabinoid Function in the CNS: Cannabinoid Neurobiology: Bridging Basic Science, Big Data, Biomarkers and Bedside Applications Across the Lifespan final speaker and discussant roster! Registration is still open! RT please! @CeceHillard grc.org/cannabinoid-fu…
Very interesting study. They did use 1000 mg CBD. It’d be good to know if this also happens at lower doses.
Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial | Neuropsychopharmacology nature.com/articles/s4138…
Recent Analysis: Cannabis Use Trends in the U.S. (1979–2022) 🔹 Design: Secondary analysis of 27 national surveys 🔹 Data: NSDUH & predecessors (n = 1.64M) 🔹 2022: Past-year use = 12.6%, past-month = 10.1% 🔹 Daily or near daily use rose 15× since 1992—now exceeds alcohol 🔹…
#ThisWeekInNPP #Cannabidiol (CBD) ⬇️ alcohol consumption & withdrawal in 🐀 by normalizing BLA excitability & protecting striatal neurons - a promising step toward innovative #AUD treatments #Neuroprotection #AddictionResearch // @giodeguglielmo nature.com/articles/s4138…
Excited to share our latest paper in @npp_journal! Chronic CBD mitigates alcohol dependence, reduces withdrawal symptoms, & offers neuroprotection in BLA & striatum in rat AUD models. Congrats to 1st author @neuroselo! Thanks to @cmcr_ucsd funding for the pilot that sparked this.…
What do we know about the endocannabinoid system in developmental psychopathology? 🤔 Find out in our recent paper, led by @pact_lab postdocs Ryann Tansey & @MarcDFerger + collaborator extraordinaire Hilary Marusak 👇 acamh.onlinelibrary.wiley.com/doi/10.1111/jc…
MitoTracker transfers from astrocytes to neurons independently of mitochondria biorxiv.org/content/10.110…
Getting all my science questions out today: anyone aware of a CCK-Cre rat? Please RT!
sciencedirect.com/science/articl… New paper from our lab with @BryanJenkinsPhD and @CassieMoorePhD CBD interactions with THC may not be what you expect
Congrats to the BioSyft.Inc team, lead by Dr. Antony English, who won two Entrepreneurship prices to further develop their cutting-edge technology that leverages AI to track natural behaviors in mice, and how it is influenced by drug treatment. @endocannabinoid
Very proud of Dr. Antony English, who recently successfully defended his PhD in front of an esteemed committee. He was co-mentored by myself and close collaborators, Dr. Michael Bruchas and Ben Land. @cannabis @endocannabinoid @Graphtablet @mbruchas
We published In ACS J. Med. Chem. We used metabolomics and computational simulations to map CBN's metabolic fate. We identified that CBN-11-OH increased calcium signaling in sensory neurons suggesting a mechanism for pain relief. pubs.acs.org/doi/10.1021/ac…
Excellent opportunity at @CRCHUM @UMontreal: Assistant or Associate Professor (tenure-track type) in Addiction and Mental Health can-acn.org/assistant-or-a…
Mitochondria and cancer: check out this important study emphasizing mito calcium signaling. Congrats to my close collaborator Dr Yasemin Sancak @yasesancak
Thank you Dipayan! There’s indeed a lot more to mito calcium than the TCA cycle!
The 2025 GRC on Cannabinoid Function in the CNS: Cannabinoid Neurobiology: Bridging Basic Science, Big Data, Biomarkers and Bedside Applications Across the Lifespan final program is here! Spots are going fast! Register soon for trainee talks! RT please! grc.org/cannabinoid-fu…
Its a long weekend here in Canada, which seems appropriate to mourn our recent @npp_journal paper, in which we find that FAAH inhibition does NOT improve symptoms in PTSD🙁 A heroic effort w/ @canna_brain @Heilig_Lab @ConnorHaggarty & many more 🧵⬇️ nature.com/articles/s4138…
Capitalising on GPCR modulation via intracellular sites to drive biased signaling for the development of precision pharmacology targeting GPCRs - interesting read doi.org/10.1038/s44386…
🚨 New in J. Med. Chem.! @ACSPublications Our novel peripheral CB1R antagonist BNS808 shows potent anti-obesity effects with minimal brain penetration, paving the way for safer cannabinoid-based therapies. Synthesis and Pharmacological Characterization of Novel Peripheral…