Ekihiro Seki
@SekiEki
Professor of Medicine | Director Basic Liver Research | @CedarsSinai
Dr. Jieun Kim will present “Chronic alcohol consumption promotes #pancreaticcancer liver metastasis in mice through PAD4-mediated pre-metastatic niche formation” at 2:50PM in the “Molecular Underpinning of #Metastasis” session. #AACR25 @AACR @SekiEki
Very excited this is out today...
Antibiotic treatment during influenza infection has harmful immunologic consequences via recruitment of eosinophils to the lungs that increases the risk of developing a secondary bacterial infection @jclinicalinvest jci.org/articles/view/…
Super excited to share our recent publication in PNAS by Rui Zhang et al. describing how using CRISPR to remove pH sensitivity of NCX1 helps maintain its function during acidosis, which is cardioprotective during ischemia/reperfusion. pnas.org/doi/10.1073/pn…
The ERV/Zbp1 pathway as a potential approach in alcohol-associated liver disease. jci.org/articles/view/…
Out now: Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease: jci.org/articles/view/… @_Noecabre @MFdezFondevila @Bernd_Schnabl & team @UCSanDiego reveal patients with alcohol-associated liver disease have increased expression of human ERVs…
A new study in @NatureComms highlights the role of glutamate storage and release in mediating alcohol-related #steatohepatitis. go.nature.com/44yMRWp
Out now: Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease: jci.org/articles/view/… @_Noecabre @MFdezFondevila @Bernd_Schnabl & team @UCSanDiego reveal patients with alcohol-associated liver disease have increased expression of human ERVs…
Combination Therapy of TERN-501 and TERN-101 (THR-B and FXR) are now published @NatureMedicine @AlkhouriNaim @DrLoomba #livertwitter @NoureddinNabil @NASH_and_coffee @SekiEki nature.com/articles/s4159…
Dr. Sergey Grivennikov @SGrivennikov will co-chair the #AACR225 mini-symposium “#Cancer Models: Mechanisms and Therapies” taking place today at 2:30pm CT. @AACR
Get out your marshmallows for another chat by the fire! The Future of Biomedicine with @Paulwnoblemd Dr. Julie Louise Gerberding, Dr. John P.A. Ioannidis @VictorDzau, Dr. George D. Yancopoulos @JointMeeting @A_P_S_A #JointMeeting2025
New! Online now: Circulating glycerate predicts resilience to fructose-induced hepatic steatosis dlvr.it/TKJTX5
In colorectal cancer, liver metastasis is enhanced by fat build-up in the liver, but the mechanism was unclear. ASCI member Ekihiro Seki & team @CedarsSinai now show steatotic liver alters the fibrotic tumor environment, and inhibition of HA synthesis by 4-MU attenuates the…
In colorectal cancer, liver metastasis is enhanced by fat build-up in the liver, but the mechanism was unclear. Ekihiro Seki & team @CedarsSinai now show steatotic liver alters the fibrotic tumor environment, and inhibition of HA synthesis by 4-MU attenuates the effect in mice:…
JCI - Metastatic Tumor Growth in Steatotic Liver is Promoted by HAS2-Mediated Fibrotic Tumor Microenvironment jci.org/articles/view/… Our paper came out! We found one of the mechanism of how steatotic liver enhances CRC liver metastasis. @CSCancerCenter @CedarsSinaiMed
New research out of Cedars-Sinai Medical Center demonstrated that steatotic liver modulated a fibrotic TME to enhance #metastatic cancer activity through a bidirectional regulation between CAFs and metastatic tumors. @jclinicalinvest 🔁 bit.ly/4k2g4OT
Vijay Pandyarajan, MD, PhD - American Liver Foundation liverfoundation.org/medical-profes… congrats, Vijay! Thank @americanliverny for the support @CedarsSinaiMed @CSCancerCenter @CSCancerCenter
ALF announces recipients of 2024 Liver Scholar & Postdoctoral Research Fellowship Awards. These awards help early career scientists dedicated to understanding liver biology, discovering mechanisms of #liverdisease, advancing treatments for liver conditions liver.news/oss
Dr. Ju Dong Yang @JuDongYang1 is corresponding author on the @NatRevGastroHep paper “Current and Emerging Strategies for the Prevention of #Hepatocellular #Carcinoma.” This examines preventive strategies and categorizes them by their mechanism of action. nature.com/articles/s4157…
Dr. Ju Dong Yang @JuDongYang1 is corresponding author on the @NatRevGastroHep paper “Current and Emerging Strategies for the Prevention of Hepatocellular Carcinoma” reviewing preventive strategies & highlighting paths to reducing #hepatocellularcarcinoma. nature.com/articles/s4157…
Great first day with great science on alcohol associated liver disease: 3rd Johns Hopkins DELTA Center Symposium on Alcohol-associated Hepatitis: Pathogenesis, Treatment and Challenge