ASCI
@the_asci
Founded in 1908, the ASCI is home to 3,000+ physician-scientists active across academic medicine and industry.
No small potatoes! ASCI member Martin E. Fernandez-Zapico & team @MayoClinic identify the nuclear envelope protein Emerin as a regulator of nuclear size in KRAS-driven pancreatic cancer. Complete report: insight.jci.org/articles/view/…
TRAPα/SSR1 polymorphisms are associated with type 2 diabetes, but the role for TRAPα in islet beta cells was unknown. ASCI member @peterarvan & team @umichmedicine discover Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis in mice:…
Spotlight: ASCI YPSA Raghu Chivukula 👇
Why do some genetic mutations devastate specific tissues while sparing others? We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain. 🧵 on our new paper in Science: 🔗 science.org/doi/10.1126/sc…
Susceptibility to Mycobacterium tuberculosis is influenced by genetic factors. ASCI member Thomas R. Hawn and team @UWMedicine perform a genome-wide association study in myeloid cells and identify multiple variants and pathways associated with clinical tuberculosis…
Pancreatic Ductal Adenocarcinoma: The Everest of Cancer Biology ASCI member @BenStanger01 @PennMedicine introduces the JCI review collection on pancreas cancer. Full report: jci.org/articles/view/…
The neonatal intestinal tract contains bacteriophages that influence the gut microbiome, but their origins were unclear. ASCI member @bollyky & team @StanfordMed now report matching phage sequences present in maternal cord blood and umbilical cord blood. Full report:…
Finding success with demethylating drugs in preclinical models of a deadly malignancy— ASCI member Kevin B. Jones & team @UUtah report on hypomethylation of CpG islands in synovial sarcoma and the use of decitabine and azacytidine in the inhibition of tumor growth:…
How does luspatercept relieve anemia in myelodysplastic syndromes? ASCI member @Amitvermamds & team @EinsteinMed discover splicing of erythroid transcription factor is associated with therapeutic response in MDS: jci.org/articles/view/…
A novel way to restore neurofibromin levels in Neurofibromatosis type 1— ASCI member @wade_clapp & team @IndianaUniv demonstrate correction of neurobehavioral deficits in a preclinical NF1 model: jci.org/articles/view/…
Out now: Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease: jci.org/articles/view/… ASCI member @Bernd_Schnabl & team @UCSanDiego reveal patients with alcohol-associated liver disease have increased expression of human ERVs compared with…
Harnessing lymphocyte self-renewal in immunotherapy: jci.org/articles/view/… ASCI member Steven Reiner's review describes signaling pathways in T cells that balance regenerative and differentiated states, which may be leveraged to boost the efficacy of immunotherapies and…
Ameliorating myeloproliferative neoplasms with cyclosporin A in preclinical models— ASCI member Peng Ji & team @PengJi_lab @NUFeinbergMed discover PPIL2 as a target of the JAK2/STAT5 pathway that promotes myeloproliferation through p53 degradation: jci.org/articles/view/…
Endometriosis and its links to ovulation: jci.org/articles/view/… Endo is a chronic, painful condition that remains difficult to diagnose and adequately manage. ASCI member @SerdarBulun's review asserts that suppressing ovulation should be a goal for managing this disease.
A crab-eating macaque with a spontaneous mutation bridges the gap between preclinical and clinical research for an inherited macular disease— ASCI member Elia J. Duh & team @HopkinsMedicine present the first non-human primate model of Best vitelliform macular dystrophy Complete…
Tissue-resident memory T cells persist long-term in the skin and gut where they can activate upon infection, but their temporal development was unclear. ASCI member @ThomasKupper3 and team @harvardmed analyzed gene programs from intraepithelial lymphocytes in skin and small…
Evidence of HIV-1-associated DNA and RNA can be found in multiple tissues despite adequate anti-retroviral therapy. Research letter by ASCI member H. Clifford Lane & team @NIAIDNews out now: jci.org/articles/view/…
An insider’s guide to understanding and obtaining an NIH K career development award- ASCI member Don C. Rockey et al. @MUSChealth provide advice to physician-scientist applicants: insight.jci.org/articles/view/…
Understanding the predictors of metabolic dysfunction-associated steatotic liver disease— ASCI member Peter Crawford @ketonemics & team @umnmedschool suggest ketogenesis serves a protective role in MASLD-MASH progression via processes other than fat oxidation:…
In glioma, T cell immunotherapies are limited by the quantity of available T cells. ASCI member @PeterFecci & team address this challenge in preclinical models by peripheral injection of autologous T cells after pre-treatment with IL-7. Full report: jci.org/articles/view/…
Urinary biomarkers that predict the progression of diabetic kidney disease! ASCI member @KidneydrChirag & team evaluated over 1000 participants with T2D and suggest EGF and UMOD as candidate biomarkers in diabetic kidney disease. See full report: insight.jci.org/articles/view/…
