Sanim Rahman
@SanimRahman4
Postdoctoral Fellow at Penn (Greenberg Lab) | JHU ‘25 (Wolberger Lab) | USF '19 (Varma Lab) |
I am thrilled to share the main product of my PhD! Let's roll out an interesting story on the H2AK119 DUB USP21 where cryo-EM, in silico PPI screening, and AF3 modeling reveal a novel mode of DUB activity and regulation... biorxiv.org/content/10.110… (1/8)
I am thrilled to share a preprint of my PhD project revealing the cryoEM structure of Haspin kinase bound to nucleosome at a DNA supergroove! biorxiv.org/content/10.110…
📢 Call for proposals: Boltz small-molecule design collaboration! 🧬 Can we help design your ideal molecule? Can you help us improve our open-source models? Please reach out or share with scientists you know! More details below! It has been great to see the level of excitement…
At this point, I don’t think anyone’s job is safe at HHS. What an insane move…
Dr. Richard Youle was among at least 10 principal investigators who were fired as part of Robert F. Kennedy Jr’s devastating reduction of federal employees working in public health.
Thrilled to share that my work from postdoctoral research has been published in @Nature . Huge thanks to my mentor Dr. Edward Twomey, and collaborators Elisa Carrillo and Prof. Vasanthi Jayaraman. nature.com/articles/s4158…
Please see our discovery of first-in-class BRISC deubiquitylating enzyme inhibitors rdcu.be/edRwF. A great journey with Elton Zeqiraj, Francesca Chandler, Joe Salvino. High-throughput screens, cryo-EM structure and ontarget activity to reduce inflammatory signals.
Excited to relocate my lab to @JohnsHopkins and join as a @JHU_BDPs! We are actively recruiting at all levels—seeking talented scientists passionate about cracking the codes of the epigenome. Let’s push the frontiers of transcription, DNA repair, and structural biology together!
Welcome Yuan He, who joins @JohnsHopkins as the Bloomberg Distinguished Professor of Structural Biophysics and Chromatin Biology. A celebrated biologist, He is joining the @JHUEpigenome BDP cluster. (1/4) hub.jhu.edu/2025/01/02/yua…
Trick bacteria with light! It took us a very long time to publish this work, but perseverance and teamwork prevailed. @ Ryan McQuillen @novayang1112 @ Amilcar Perez @Malcolm Winkler @ Erin Goley @ Kumaran Ramamurthi nature.com/articles/s4146…
Pleased to present our first preprint on how de novo DNA methylation occurs in di-nucleosomes. Lots of surprising findings about the linker length dependence of DNMT3 binding and activity. A great collaboration with the Peter Jones lab @VAInstitute. tinyurl.com/47pmv7hy
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
A tour de force from Carl Wu's lab @JohnsHopkins .- lead author postdoc Robert Louder: Molecular basis of global promoter sensing and nucleosome capture by t... sciencedirect.com/science/articl…
Another group has more or less reproduced AF3, but has built in a way to add spatial constraints for PPI prediction. These constraints lead to huge increases in fraction of models that are correct-ish, without changing fraction that is high-accuracy chaiassets.com/chai-1/paper/t…
Excited to share that our paper on transcription repression after DNA double-strand break is online. Great collaboration with @taekjip and @yliu_UofU, spearheaded by Shuaixin He @BiophysicsJHMed @BCMB_JHMI cell.com/cell-reports/f…