Prof Sam El-Osta

What is the role of Set7 methyltransferase in diabetic glomerular endothelial cell damage in diabetic kidney disease? This study shows Set7 regulates the mesenchymal to endothelial phenotypic switch. journals.lww.com/jasn/fulltext/…

Stem cell derived islet therapy restores insulin in people living with T1D 🔹 100% showed C-peptide response 🔹 100% avoided severe hypos + HbA1c <7% 🔹 83% achieved insulin independence at 1 year 🔹 All received single infusion + immunosuppression nejm.org/doi/full/10.10…

Still buzzing from the 20th IPITA Congress in Pisa! Too many highlights to name, one standout was Dr. Deng’s talk on Chemical Reprogramming for Cell Fate. Stellar program & speakers, meeting new friends and staying at the historic Galilei residence, home of Galileo’s family!

🚨 Out now in Circulation Research 🚨 So proud with @mkontari to launch this Compendium on Interorgan Crosstalk in Heart Failure & Cardiometabolic Disease. Heart failure it’s systemic. Multiorgan. Dynamic. @CircRes @dzhk_germany @dhzcharite @MDC_Berlin

"Scalable co-sequencing of RNA and DNA from individual nuclei" - cool new method! nature.com/articles/s4159…

Please all join our General Assembly @ishr2025 in Nara - room A&B today at 14:00! @ISHR_AUS @ISHR_NAS @ISHR_chinese

Epigenetic changes affect the function of the glucose transporter DNA in endothelial cells from FCD2tissue….The role that decreased glucose tissue concentration in FCD 2 tissue remains unknown… future research is designed to uncover the significance and mechanisms in #epilepsy!

*Diabetes impairs blood vessel growth, worsening PAD outcomes *Study finds high glucose boosts SETD7, increasing SEMA3G-an angiogenesis blocker-restoring vessel formation in diabetic cells, mice, and patients *Targeting SETD7 may offer a new epigenetic therapy for diabetic PAD

Proud to share our latest work! Out today in @CircRes @CTECresearch @FrancescoPaneni @shafeeq_moham @NataliaAtzemian @GoricaEra @Lux_Telesca @alesmengozzi @mongelli @LDiVenanzio

Our lab has identified a new epigenetic mechanism and a druggable target in #HFpEF. Extremely thankful to my amazing team and our fantastic collaborators! @CircRes @UZH_en @Unispital_USZ @CTECresearch @PaneniLab ahajournals.org/doi/10.1161/CI…

New! Online now: O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles dlvr.it/TK4lJ4

🧵 Should you integrate single-cell RNA-seq datasets or not? You've got PBMCs from multiple donors. Merge them—or keep them separate? Let's break it down.

Check out this new @ClevelandClinic study uncovering glucose metabolism in focal cortical dysplasia is linked to epigenetic GLUT1 regulation. Congrats to Chaitali and team led by Imad Najm @imadmnajm @CleClinicNews link.springer.com/article/10.100… #epilepsy #neuroepigenetics #GLUT1 #FCD

New online! The genetic basis of human height bit.ly/4crXfl6

Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming dlvr.it/TJyJMT

Lactate controls cancer stemness and plasticity through epigenetic regulation dlvr.it/TJwtQM

Looking for a new research assistant to join our team @HRIAust . If you have an interest in the #heart and #cancer please apply. @ISHR_AUS

In a new Science study, researchers introduce GAIA, a statistical approach that seeks to learn the geographic position of every genetic ancestor of individuals included in a genome dataset. Learn more ⬇️ 📄: scim.ag/4l79zLb #SciencePerspective: scim.ag/41Owy6f