CTEC - Zurich University Heart Center

🚨Latest piece from #Saeedi_Lab is out in @NatRevCardiol. This article highlights the need for looking beyond gut #microbiome composition to focus on its #metabolites as modifiable #cardiovascular & #aging risk factors. @CTECresearch @Unispital_USZ @CardioZurich @FrancescoPaneni

Sudhahar & colleagues found #exercise protects blood vessel in #diabetes by turning on natural #antioxidants (#SOD3) that produce physiological levels of hydrogen peroxide to keep blood vessels healthy. Learn more at ahajrnls.org/3IU4wz5

🔥Hot off the press from the #Saeedi_Lab! Featured in Nature Reviews Cardiology (@NaturePortfolio ). 🔎From gut bacteria to their metabolites, this piece traces 100+ years of microbiome science, showing how gut-derived compounds 🦠 can drive 🫀cardiovascular aging.

💡The future? Targeted, personalized therapies based on our gut’s chemical output. 👏 Congrats to @SoheilSaeedi5 & team! 🔗 Read the paper here: lnkd.in/eHkNWkvh @FrancescoPaneni @GoricaEra @shafeeq_moham @NataliaAtzemian @LDiVenanzio @Lux_Telesca @TDiteepeng @CardioZurich

🎯 Meta-analysis to provide the NNT and efficacy of GLP-1RA in reducing risk of myocardial infarction (MI). 👥109,846 pts from 25 studies. Risk-reduction effect of GLP-1RA were pooled using pairwise meta-analysis with a random-effects model. The primary outcome was MI, and…

What a joy to wrap up the first half of 2025 with an exciting #CTEC meeting and summer soiree! A wonderful get together to discuss science and celebrate our recent achievements in research and funding. So proud of such an amazing team! @CTECresearch

🫀 Cardiometabolic HFpEF phenotype (cmHFpEF) is rising fast, linked to obesity, hypertension, and chronic inflammation. 🔬 New insights reveal how metabolic stress, immune shifts, and epigenetic changes drive this condition. 🧬 Targeting metabolism, inflammation & chromatin…

📣 The next @CTECresearch webinar is around the corner! Join us this Friday for an exciting session. In his talk, Professor @PasqualeMaffia from @UofGlasgow will delve into immune dysregulation in cardiovascular disease, from novel mechanisms to therapeutic targeting. 🧬

🎯To evaluate the relationship between CMR-imaging and pro-fibrotic/inflammatory serum biomarkers, to discriminate HFpEF from associated comorbid conditions. 👥Prospective cohort study of 35 obese participants (mean age 64 ± 8 yrs, 23% females), including: - 16 with T2DM - 13…

🚨The latest work from @PaneniLab is out! We explore the journey from molecular signatures to personalized treatment in #cmHFpEF. Heartfelt thanks to all the authors their for their contribution. Special thanks to my PI, @FrancescoPaneni , for his invaluable supervision!