Bharath Srinivasan

Which is the most important equation in biochemistry?This article discusses the history of Michaelis-Menten equation, the assumptions that went into its derivation & its limitations. RT doi.org/10.1111/febs.1… @TeachingSTEM @STEMEduc @StemEdCoalition @science_4_all @FEBSJournal

Our story on providing N-OH moities by means of #flavoprotein #monooxygenases for the #cascad# towards N-#hydroxytriazenes just moved online! The promiscuous N-hydroxylating monooxygenase GorA and its application in cascades: Cell Reports Physical Science cell.com/cell-reports-p…

Covalent inhibitors are characterized by a ratio of two constants. @bharath_IGC  explains that considering both, and how one affects the other, could help advance hits on difficult targets: practicalfragments.blogspot.com/2025/07/the-im… @JMedChem @CR_UK @ACSBioMed

Entabolons: How Metabolites Modify the Biochemical Function of Proteins and Cause the Correlated Behavior of Proteins in Pathways pubs.acs.org/doi/10.1021/ac… @bharath_IGC @Brice_Edelman #JCIM Vol65 Issue11 #Bioinformatics

Excited to share a perspective I wrote on the evolving role of irreversible inhibitors in drug discovery published in the @JMedChem. I would specifically like to thank Henry Blackwell for his immense contribution. @CR_UK , @ACSBioMed

Excited to share this article sharing my perspective on design principles for irreversible modulator optimisation.

Delighted to share our manuscript Entabolons: How Metabolites Modify the Biochemical Function of Proteins and Cause the Correlated Behavior of Proteins in PathwaysClick to copy article link pubs.acs.org/doi/10.1021/ac…

Please share! Competitive PhD studentship on Diffuse Midline Glioma and Ferroptosis in my group @ Queen's University Belfast. Deadline = 6th May. qub.ac.uk/courses/postgr…

Thanks for coming. I really look forward to meeting you again @AdrianMulholla1

Esta es la famosa Foto 51 de Rosalind Franklin, primera imagen del ADN y símbolo de precisión, descubrimiento y mirada al interior de la vida. Esta imagen cambió la forma de entender la vida. Hoy nos inspira a cambiar la forma en que nos mostramos al mundo. #CNBrebranding #DNAday

My painting TIDAL WETLANDS

We barely understand how life lives. Even though this metabolic map looks impressive, it's just a fraction of the interactions and cycles possible in nature and even these are a gross oversimplification of the nuance at play. This is the goopy chaos I adore.

Reimbursement, pt. 2

Thrilled to share our new covalent AKR1C3 inhibitor targeting a non-catalytic tyrosine (Y24) with proteome-wide selectivity! An enabling tool for probing metabolism in hormone-driven cancers. Big congrats to Justin Grams from my team! pubs.acs.org/doi/full/10.10…

I am thrilled to share the second part of our editorial series on "Quantitation and Error Measurements in Dose–Response Curves," published in Journal of Medicinal Chemistry! A huge thank you to my co-author @DrMatthewLloyd for our ongoing collaboration on this series @JMedChem

I am very happy to share this new editorial with Dr Bharath Srinivasan.

The public has a distorted view of science, because children are taught in school that science is a collection of firmly established truths. In fact, science is not a collection of truths. It is a continuing exploration of mysteries. - Freeman Dyson

It is very sad to learn that Martin Karplus passed away on Dec 28 at age 94. He was a scholar and pioneering chemical physicist with great contributions in many areas including molecular dynamics. We interacted many times starting from my graduate time at Harvard. His legacy is…