Subhojit Roy
@Roy_Lab_Thinks
Science. Music. Sometimes funny. https://www.youtube.com/channel/UCd_bJwirwOnBeTb8K-t0xyA
Massive 10+ year effort in lab spearheaded by @leonardoaparrar and Kayal (secret account 🤔). Unreal cover by @EmmaVIDALL that says it all.
2023's final issue is out! cell.com/neuron/current Cover story is from @Roy_Lab_Thinks's lab revealing an unexpected physiologic role for α-synuclein phosphorylation in clustering synaptic vesicles and restricting neurotransmitter release. Read it here cell.com/neuron/fulltex…
If you're tired of AI and stuff...we published CRISPR-based protocols that you can actually use to delete alpha-synuclein (~100% efficiency) or knock it into endogenous locus (~53% eff) in cultured neurons: star-protocols.cell.com/protocols/4339
Woha Kaun Hai Tera..Musafir (Guide 1966) #melodica #melodicacover #roli ... youtu.be/mbnk-U9V6Nc?si… via @YouTube
Grant terminations have grabbed the headlines and have seen legal action, but even more damaging to the US research enterprise has been the massive decrease in research grants issued by federal agencies NIH: -57% in the number of awards and -63% in value compared to FY24
You're not depressed, you just need a quest.
While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! I wrote an article outlining this in @GENbio genengnews.com/topics/transla…
Submit concerns by 5pm ET 7/14 go.pardot.com/e/858023/ducin…
Timely reminder...
Journal of Cell Science is published by a not-for-profit charitable organisation (@Co_Biologists) that exists to benefit science, not shareholders. We provide Travelling Fellowships, Training Grants, support for ECRs and more. For details, visit: journals.biologists.com/jcs/pages/reas…
From grief to glory - Akash Deep's spell of a lifetime espncricinfo.com/story/eng-vs-i…
How will labs work without money? "No one at NIH can do anything" is the answer I got from someone high up. Goal seems to be to strangle #scientists out. If you don't think it's happening to you, just wait.
NIH is slow to send funds for non-competing renewals. This is disrupting research in many labs, including mine. I was expecting payment for one NINDS grant 2 months ago, but I'm still waiting. I don't understand exactly why this is happening. It'd be impossible for us to…
Revisions become supplementary figure lollapaloozas addressing every reviewer/editor whim and fancy. Meanwhile everyone complains about publishing...
PI after getting revisions from postdoc who thinks revised paper can be submitted this wednesday...
"...in the life of civilizations as in the lives of individuals too much matter that cannot be digested, too much experience that has not been imagined and probed and understood, ends in total rejection of everything — ends in anomie"
This is wonderful: Poet May Sarton on how to live openheartedly in a harsh world themarginalian.org/2023/01/01/may…
p-tau is high in newborns, p-Ser129 seen in normal brains (cell.com/neuron/fulltex…), Abeta is present in cognitively normal folks, & high cholesterol doesn't always cause cardiac arrest. Repeat after me: Chronic disease is not like Infectious disease. academic.oup.com/braincomms/art…
"FOCUS is your most valuable resource"
Stanford paid 35,000 people to quit social media. This was the largest study on emotional health in history. The results were so shocking, scientists called it "comparable to therapy." Here's what happens when you break free from the algorithm: 🧵
nature.com/articles/s4156…
CRISPR just scored its biggest win yet against Huntington's. The secret? A delivery system called RIDE that sneaks into neurons, makes its edit, then vanishes in 72 hours. Here's what happened 🧵👇
Ted Koppel interviews my Hopkins colleague Prof. Liz Jaffee, world expert in pancreatic cancer, about the devastating cuts and slow roll out of cancer research funding by the NIH. See this CBS Sunday morning show video here: youtube.com/watch?v=CLwcYQ…
...by paying more.
Researchers funded by the NIH will be required to make their scientific papers available to read for free as soon as they are published go.nature.com/3Gh7Rr8
Yup. Same. Please stop acting like it’s business as usual while NIH isn’t funding grants.
My NIDA grant renewal is almost 2 months late and I’m going to have to start firing my students and staff. Not a lot of transformation to be had in my lab.
Impromptu 2 AM bar hop with the kids at #Alzheimer @GordonConf #Ventura #California
Epic roast
I mean, I guess I could lose a few pounds, but as I get close to 70 yo, hopefully Joe will look as good. Here I am in a new pic with my pretty wife Ann of almost 40 years of marriage. In the meantime I helped pioneer low cost vaccines that have reached 100 million people