Rossjohn lab
@RossjohnLab
Led by Prof @Jamie_Rossjohn FRS we are focused on understanding molecular bases underpinning protective and aberrant immunity
In collaboration with labs @PN0rmski @KatherineKedz @AndrewB34372462 @syctong and co-authors, paper published @MonashUni: An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania: Cell cell.com/cell/fulltext/…
Early bird registration pricing for CD1-MR1 2025 ends this Friday, 6th June! Get on it 👉👉 cd1mr1.com
Congrats to Hien, 1st author of this study that arose from her hard work during her PhD.
Latest research from @jbiolchem “The molecular basis of T cell receptor recognition of citrullinated tenascin-C presented by HLA-DR4” by Dao et al. jbc.org/article/S0021-… @ASBMB @Jamie_Rossjohn
In collaboration with Moody lab, latest paper from @RossjohnLab describing the structure of a lipopeptide bound to a MHC-I like molecule found in chickens - hopefully this study will not ruffle too many feathers.
Your immune system gradually loses it top team players when we get older 👱➡️👵 Our study in @eBioMedicine investigates how long our good immune cells stay around – a 🧵⬇️ go.unimelb.edu.au/4sep @CvandeSandt @KatherineKedz @TheDohertyInst #Influenza #AgingResearch
Our latest paper demonstrating the potential of “our” DOT cells against colorectal cancer has just been published in @NatureCancer: rdcu.be/ehYwG Many congrats to the whole team, especially @RafaelBlancoDom! :)
Recent paper from lab describing a peptide-independent MHC-restricted T cell receptor nature.com/articles/s4146… in collaboration with La Gruta lab @MonashUni @Monash_FMNHS @RossjohnLab @NatureComms
In collaboration with @NicoleLaGruta1 and colleagues, latest paper from @Jamie_Rossjohn lab describing role of Lck-coreceptor assocation in T cell function. @MonashUni science.org/doi/10.1126/sc…
Researchers in Science #Immunology have identified CD8+ T cells from human donors that can recognize naturally occurring influenza variants spanning more than 100 years, including the 1918 influenza A and 2024 #H5N1. @Jamie_Rossjohn @kedzierskalab scim.ag/4hpSzh1
🚨 Flu breakthrough! 🚨 Researchers at @TheDohertyInst & @MonashUni have discovered immune cells that recognise flu viruses even as they mutate—a further step toward a universal flu vaccine. go.unimelb.edu.au/d7z8 @UniMelbMDHS @TheRMH @oanheei @Jamie_Rossjohn @kedzierskalab…
Our latest study @SciImmunology identifies the molecular determinants of cross-reactive B35/NP418-restricted CD8+ T cells across IAVs from 1918 H1N1 to 2024 H5N1, and assesses their functionality. @KatherineKedz @RossjohnLab science.org/doi/10.1126/sc…
TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants @SciImmunology science.org/doi/10.1126/sc… @RossjohnLab @Jamie_Rossjohn @kedzierskalab @KatherineKedz
science.org/doi/10.1126/sc… First paper from the @JohnstoneLab for the year and a brilliant collaboration with @TheDohertyInst colleagues Dan Utzschneider and Alex Kallies. Thanks to all @PeterMacRes @PeterMacCC for help and support and great job Dane Newman and Leonie Cluse!
Researchers paid $8.968 billion for their findings to be freely accessible. 🧵1/10
Latest paper from lab, where Awad et al describe how cigarette smoke impacts that MAIT-MR1 axis and implications for lung diseases. In collaboration with Fairlie, Hansbro and Corbett labs doi.org/10.1084/jem.20… @MonashBDI @nhmrc @WaelAwadMoh @MonashUni @Jamie_Rossjohn @JExpMed
Fast and accurate modeling of TCR-peptide-MHC complexes using tFold-TCR 1. tFold-TCR introduces a high-throughput, end-to-end method for predicting TCR-peptide-MHC (TCR-pMHC) complex structures, overcoming challenges in TCR-pMHC interactions and enabling rapid and precise 3D…
@Immutep in collab with @RossjohnLab first to publish structure of LAG-3/HLA-II complex & resolve how human LAG-3 binds to its main ligand, providing better foundation for development of blocking #LAG3 therapeutics incl its own small molecule program. bit.ly/3DkXnp2
latest paper from the lab describing crystal structure of the human LAG-3-HLA-II complex, in collaboration with @Immutep @MonashUni @SciImmunology @arc_gov_au @Jamie_Rossjohn science.org/doi/10.1126/sc…
Tokyo qualified! 💥 Isobel Batt-Doyle storms home in 2:22:59 at the Valencia Marathon, finishing 8th overall in the women's field. Izzi also met the qualifying standard for the Tokyo World Athletics Championships next September after skyrocketing to third on the Australian…