Roman Teo Oliynyk, PhD

Heritable polygenic editing: the next frontier in genomic medicine? nature.com/articles/s4158…

Circular Vector (CV) protocol describes a synthetic, cell-free approach for preparing transfection-ready, small, double-stranded DNA templates for gRNA expression for genome-editing applications doi.org/10.1038/s41596…

Meet BOSS, the largest discovered structure in the universe so far, a wall of galaxies at over a billion light-years across.

Striking Departures from Polygenic Architecture in the Tails of Complex Traits biorxiv.altmetric.com/details/170928…

📢 無料公開論文のお知らせ Title: Contribution of rare variants to heritability of a disease is much greater than conventionally estimated: modification of allele distribution model 著者: Yoshiro Nagao ら 無料公開期間: 2024年9月21日まで 🔗 詳しく読む nature.com/articles/s1003…

Contribution of rare variants to heritability of a disease is much greater than conventionally estimated: modification of allele distribution model nature.altmetric.com/details/166512…

Prevalence of errors in lab-made plasmids across the globe biorxiv.org/content/10.110…

We are proud to announce this preprint of a groundbreaking study introducing Plasmid2MC, a new method for creating high-purity minicircle DNA, important for genome editing applications. biorxiv.org/content/10.110…

Phys. Rev. Research 6, 023189 (2024) - Runaway transition in irreversible polymer condensation with cyclization journals.aps.org/prresearch/abs…

Roman Teo Oliynyk @harvardmed and @uoacompsci used wolf telemetry data to show that human-caused wolf mortality persists after discontinuation of hunting nature.com/articles/s4159…

Once a species gets off the #endangered species list, how do we keep them off? Wyss researcher @RTOliynyk found that the mortality rate of wolves in MN nearly doubled after a three-year trophy hunt & remained persistently elevated after the hunt end. nature.com/articles/s4159…

Wolf hunts drastically increased human wolf killing for more than 5 years after hunts ended! #endangeredspeciesact #Banwolfhunting #relistwolves @interior @SenatorBaldwin @usfws @senamyklobuchar @amyklobuchar disq.us/t/4hilz2w

Human-caused wolf mortality persists for years after discontinuation of hunting disq.us/t/4hilz2w Overall wolf mortality trend doubled and human-caused mortality increased 3.5X with Minnesota hunting seasons 2012-2014 and remained elevated through 2019 dataset

Contribution of rare variants to heritability of a disease is much greater than conventionally estimated: modification of allele distribution model medrxiv.org/cgi/content/sh… #medRxiv

A synthetic method for the production of circularized DNA containing expression elements independent of plasmids is presented, taking linear double-stranded DNA fragments which are circularized and purified ⭕️ nature.com/articles/s4200…

bioRxiv viewer disq.us/t/3moo9i4 Impressive late-onset diseases results showing sib pair predictive difference quite consistent at 1.5 --- 2.5 SD. Binning by age would be most appropriate, sample size permitting. Remove pop prevalence as of no analytical value? Great stuff!

Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective disq.us/t/3iba9j8 @PavelProsselkov @mbalter @westr

Polygenic and clinical risk scores and their impact on age at onset - The authors corroborate the earlier theoretical study "Quantifying the Potential for Future Gene Therapy" doi.org/10.3390/ijms20…. Great work, congratulations! biorxiv.org/content/10.110…

#mdpiijms Quantifying the Potential for Future Gene Therapy to Lower Lifetime Risk of Polygenic Late-Onset Diseases mdpi.com/1422-0067/20/1… @IJMS_MDPI

#mdpijpm Evaluating the Potential of Younger Cases and Older Controls Cohorts to Improve Discovery Power in Genome-Wide Association Studies of Late-Onset Diseases mdpi.com/2075-4426/9/3/… @JPM_MDPI