PfanderLab
@PfanderLab
Discovery Science in the Genome Integrity field. Opinions are our own.
Our new work lead by Lorenzo Galanti is out in @NatureComms. New function of DDK in regulating HR and DSB resection in budding yeast and human cells. Check it out here nature.com/articles/s4146…
Congratulations to the best poster prize winners Vanessa Borges-Pires, Anita Jopkiewicz, Jessica Spindler, Maximilian Götz, Na Wei, George Galea of the German Society for DNA repair DGDR meeting 2024 in Cologne @MPIAGE @CGA_age @CECAD_ @UniCologne @spanier55 @PfanderLab
Grateful for the opportunity to present our work this week, and happy to see three other former graduate students of the late Stefan Jentsch on this list @PfanderLab @RapeLab @stingele_lab. This one is for you, Stefan!
Where is the spring? Are you ready for the summer? Social DNAing is. Check out our 2024 late spring and summer speakers. The website will be updated soon: cancer.columbia.edu/research/progr…. Thank you for helping us RT.
AlphaFold3 is insane. MutS protein (green) recognizes base mismatches in DNA (gray), after which it slides off to find MutL matchmaker protein (blue), which positions and activates MutH nuclease (pink) to nick a hemimethylated GATC sequence (red) to activate removal and repair of…
Publication alert! 📰 Great job to @hopfnerlab and collaborators on the new publication in @NatureComms! Read more about it here: nature.com/articles/s4146…
Check out our latest structural paper about human OGG1 processing DNA lesions within nucleosome core particles, in collaboration with Chuanzheng Zhou's lab. #DNArepair #cryoEM nature.com/articles/s4146…
We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: tribute2angelos.fr/page/home/
@RogerRogergr we are really looking forward to your presentation at #DDRCT25 in Lisbon🌞 Registration is OPEN and we have short talk spaces available. 📣Help us spread the word - Please RT to let your followers know! Thank you! Find out more: bit.ly/3BTmZbQ
📢The deadline is approaching!! This is your last week to apply for exciting projects @IMPRS_LM in the labs of Ralf Erdmann, @kw_kliza, @hemmo_lab, @AndreaMusacchi1, @PfanderLab, Barbara Saccà, Daniel Summerer, Jörg Tatzelt, @BTrappmann, @LabWestermann & @winklhofer_lab
An intact genetic information is the fundament of life. If you are interested to apply precision genome engineering and state-of-the-art sequencing technology join the @PfanderLab @IMPRS_LM #PhDposition #IMPRS #cellbiology #DNAreplication #genomeengineering
The lab moved to the Technische Universität Dortmund - exciting times ahead: ccb.tu-dortmund.de/en/professorsh…
Pleasure to host the 2024 meeting of the German Society for DNA Repair @MPIAGE @CECAD_ in Cologne with outstanding international guest speakers and the amazing community of DNA repair researchers in Germany with @spanier55 @PfanderLab
Mechanism of homology search expansion during recombinational DNA break repair in Saccharomyces cerevisiae dlvr.it/TCxvLF
📢Are you eager to join an international community of scientists to tackle novel and exciting research projects in the areas of #biochemistry, #structuralbiology, #cellbiology, #chemicalbiology and #syntheticbiology? Applications for the @IMPRS_LM #PhDprogram are now OPEN!!!
CMG helicase disassembly is essential and driven by two pathways in budding yeast Karim Labib and colleagues show that Pif1-family helicases mediate an ancestral pathway for ‘old’ #replisome disassembly during the subsequent S-phase embopress.org/doi/full/10.10…
Check out our latest paper showing that HLTF removes Cas9 from DNA, explaining phenotypic differences when using the two Cas9 nickase variants. Important for gene editing! Thanks to @giordano_reg & Rosaria and @MartinJinek @taekjip @nussenza nature.com/articles/s4146…
Jim - being a superstar of yeast genetics has to be fantastic. People must ask you for selfies all the time... 😃
Who needs a duckboat?
How does DNA damage cause apoptosis when p53 is mutated? Critical to understand treatment of many tumors. Excited that ‘DNA damage induces p53-independent apoptosis through ribosome stalling’ by Nicolaas Boon and collaborators is out: doi.org/10.1126/scienc…
Open letter to the editor regarding #AlphaFold3 source code not being available: zenodo.org/records/112061…
The lab’s first pre-print is out! ‘A microscopy reporter for cGAMP reveals rare cGAS activation following DNA damage, and a lack of correlation with micronuclear cGAS enrichment’ biorxiv.org/content/10.110…
How does Mcm10 activate an origin of replication? Find the answer in our paper published today in @NatureSMB. Congratulations to Sarah Henrikus & our fantastic lab! 🥳🎉 rdcu.be/dIdI4 Great collaboration with Marta, Allie and John from @DiffleyLab @TheCrick