Costa Lab

@CostaLabCrick

Biochemists & cryo-EM scientists studying chromosome replication @TheCrick

The Francis Crick Institute

Joined October 2022

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508Followers

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Costa Lab@CostaLabCrick · Dec 11

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication. 8 years of funding at the Crick Institute. Looking for a postdoc in molecular mechanism, cryo-EM and in situ structure? Contact me now! 3 postdoc positions advertised soon.

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Costa Lab@CostaLabCrick · Jan 20

How does ATP hydrolysis by MCM enable replicative helicase loading onto DNA? Find the answer in our latest article rdcu.be/d6D8D Congratulations to Agata Butryn, who spearheaded the entire project, Contributions from @GreiweJulia in the early days. 🎉❄️🔬🧬

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Costa Lab@CostaLabCrick · Nov 27

Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m

CostaLabCrick's tweet image. Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳

Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m

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Costa Lab Retweeted

Bleichert Lab@BleichertLab · Nov 27

Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online @Nature! 🎉 Our findings reveal that unlike in yeast, human MCM loading does not require ORC6 and can occur through multiple pathways. Read more here: rdcu.be/d1F6S

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Costa Lab Retweeted

Anja Groth 🇺🇦@groth_anja · Nov 5

Great kickoff for the EMBO EMBL Replication symposium with amazing structural and functional insights into initiation, elongation and histone recycling 🧬♻️ @TyeBik @CostaLabCrick @BleichertLab @Speck_Lab Chistol @Lopes_Lab Méchali @YardimciLab 🙌 #EESReplication @EMBLEvents

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Costa Lab@CostaLabCrick · Sep 6

Looking forward to this!

RRafa F Leiro@rfleiro · Sep 6

A fantastic lineup of speakers for the "Machines acting on DNA and RNA" meeting at @CNIOStopCancer All things D/RNA! 🧬Replication + transcription + translation + chromatin + repair + processing🧬 May 28th to 30th, 2025 - Save the date! @OscarLlorcaCNIO @rfleiro @NogalesLab

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Costa Lab Retweeted

EMBL Events@EMBLEvents · Jul 26, 2024

⏰ Deadline approaching for #EESReplication ⏰ Submit your abstract by 13 August and find out about the latest breakthroughs in DNA replication 🧪🧬 📅 5 – 8 November 📍 EMBL Heidelberg and Virtual ➡️ s.embl.org/ees24-12

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Costa Lab Retweeted

The Francis Crick Institute@TheCrick · Jul 9, 2024

Congratulations to group leaders Snezhka Oliferenko and Alessandro Costa (@CostaLabCrick) on being elected as members of @EMBO 🥳 crick.ac.uk/news-and-repor…

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Costa Lab@CostaLabCrick · Jul 8, 2024

Abstract and early bird deadline for the 2024 UK DNA Replication Meeting is this week. Don't miss out - its going to be a fantastic meeting!

BBiochemical Society@BiochemSoc · Feb 2, 2024

Unlock the latest insights into DNA replication at our 2024 meeting. Dive into the forefront of research and deepen your understanding of this fundamental process. Register today to join leading experts and explore rapid advancements. ow.ly/jaOL50Qvt9K

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Costa Lab@CostaLabCrick · May 17, 2024

How does Mcm10 activate an origin of replication? Find the answer in our paper published today in @NatureSMB. Congratulations to Sarah Henrikus & our fantastic lab! 🥳🎉 rdcu.be/dIdI4 Great collaboration with Marta, Allie and John from @DiffleyLab @TheCrick

CostaLabCrick's tweet image. How does Mcm10 activate an origin of replication?

Find the answer in our paper published today in @NatureSMB. Congratulations to Sarah Henrikus &amp; our fantastic lab! 🥳🎉

rdcu.be/dIdI4

Great collaboration with Marta, Allie and John from @DiffleyLab @TheCrick

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Costa Lab Retweeted

Ivan Ahel Lab@IvanAhelLab · Apr 9, 2024

TWO postdoc positions available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in biochemistry/structural biology/cell biology to work on these exciting projects! Post 1: DNA damage response my.corehr.com/pls/uoxrecruit…

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Costa Lab@CostaLabCrick · Apr 11, 2024

Human origin licensing reconstituted with purified proteins. Great collaboration with Florian Weissmann & John @DiffleyLab. A cryo-EM tour de force from our @GreiweJulia.

bbioRxiv@biorxivpreprint · Apr 11, 2024

MCM Double Hexamer Loading Visualised with Human Proteins biorxiv.org/cgi/content/sh… #bioRxiv

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Costa Lab Retweeted

Thomas Miller@TCR_Miller · Jan 19, 2024

I am happy to announce that we've recently posted our new manuscript, titled: ‘Cell Cycle Regulation has Shaped Budding Yeast Replication Origin Structure and Function’ on BioRxiv (biorxiv.org/content/10.110…). We hope you enjoy! Tweetorial below:

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Costa Lab Retweeted

Jacob Lewis 🧬 📷@Jacob_Lewis90 · Jan 5, 2024

🌟 Big News! 🌟 the Lewis lab is open for business @MolHorizons. A new chapter of discovery and learning awaits. Thrilled to start this journey and tackle some challenging questions!

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Costa Lab@CostaLabCrick · Nov 16, 2023

Our study on the cover of Molecular Cell 🥳. Thanks @AgaGambus and @GS_Lab_Bham for a great collaboration. Structure by Milos Cvetkovic❄️, @PaoloPassaretti🧬, Agata Butryn👩‍🔬. Artwork by @petermindek and the nanographics.at team.

MMolecular Cell@MolecularCell · Nov 16, 2023

Our latest issue is out now! cell.com/molecular-cell…

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Costa Lab@CostaLabCrick · Oct 11, 2023

DONSON paper out! Congratulations Milos Cvetkovic and @PaoloPassaretti! Great collaboration with @AgaGambus's group. Thanks @GS_Lab_Bham for contributing. The structural mechanism of dimeric DONSON in replicative helicase activation: @MolecularCell cell.com/molecular-cell…

CostaLabCrick's tweet image. DONSON paper out! Congratulations Milos Cvetkovic and @PaoloPassaretti! Great collaboration with @AgaGambus's group. Thanks @GS_Lab_Bham for contributing.

The structural mechanism of dimeric DONSON in replicative helicase activation: @MolecularCell cell.com/molecular-cell…

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Costa Lab Retweeted

FASEB@FASEBorg · May 16, 2023

The deadline for abstract submissions has been extended to this Sunday (5/21). Share cutting-edge research on RNA and DNA helicases for a short talk or an in-person poster/e-poster. #HNASRC @PaeschkeL @Trakselis @tranforwabash Register and submit: bit.ly/3McTlQg

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Costa Lab@CostaLabCrick · Mar 1, 2023

Interested in Structure, Mechanism and Chromosome Biology? Then you should join our lab at the Crick as a PhD student! crick.ac.uk/careers-study/… Applications close on 22 March 2023. You might get a hat like Julia's, who successfully defended her thesis last week! 🥳❄️🔬🧬

CostaLabCrick's tweet image. Interested in Structure, Mechanism and Chromosome Biology?

Then you should join our lab at the Crick as a PhD student!

crick.ac.uk/careers-study/…

Applications close on 22 March 2023.

You might get a hat like Julia's, who successfully defended her thesis last week! 🥳❄️🔬🧬

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Costa Lab@CostaLabCrick · Nov 14, 2022

Congratulations to our PhD student Julia Greiwe for receiving the Crick Science Achievement Award. As part of the celebrations, Julia gave a great talk at the Crick Autumn Science Meeting last week. She described the mechanisms MCM helicase loading and phosphorylation by DDK.