PabloEsteban

Plasma Membrane Damage (0.005~0.09% SDS) induces Yeast or Fibroblast #Senescence Activating p53-p21 axis but independently of DNA damage response Roles of ESCRT (CHMP4B) & Glycoprotein VI Really interested if PMD-senescence occurs in endothelial/muscle cells, or by…

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.@LabYuseff @uc_chile show that B cells respond to mechanical cues at the immune synapse through ATAT1-dependent microtubule acetylation to coordinate cytoskeletal dynamics & lysosome positioning, enhancing antigen extraction and presentation hubs.la/Q03y2G-f0

🧬 My first paper is out in Journal of Cell Biology! @JCellBiol We show how B cells use ATAT1 to sense stiffness, acetylate microtubules, and improve antigen presentation. Proud to share this milestone 🌎💪 🔗 rupress.org/jcb/article/22… #Bcells #Mechanobiology #Immunology #PhD

How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and how does this relate to #mechanobiology? Learn more in our recent review by @SarahHenretta now out in @Nature_NPJ - biological physics and mechanics (doi.org/10.1038/s44341…).

High-Speed Multiplexed DNA-PAINT Imaging of Nuclear Organization Using an Expanded Sequence Repertoire Abhinav Banerjee et al. doi.org/10.1101/2024.1…

Image: lysosomal #exocytosis occurs in the vicinity of focal adhesions. From Wei-Wei Ren, Morihisa Fujita et al. @GifuUniv_PR showing that MYO18B promotes lysosomal exocytosis by facilitating focal #adhesion maturation. hubs.la/Q03154rr0 #Lysosomes #mechanobiology

It was a great epxerience yesterday , I hope to keep talking about nucleus and actin for a long time more #ASCB2024. @LabYuseff !!

In June '24: At the moment of T cell activation, the presence, or lack, of nuclear envelope invaginations, which gather organelles, influences effector and memory fate decisions. buff.ly/3ZzruBG From @BenHale95, @BerendSnijder et al. #Immunology #Tcells @ScienceMagazine

Felicitamos a @Cabrera_R_FE y @ContrerasTeemly por sus excelentes presentaciones orales en el XXXVI Congreso de @_SBCCh Los dejamos invitados al póster de @Peaceiton que estudia la respuesta mecánica del núcleo durante la sinapsis inmune de células B #Bcell #Mechanobiology

#FluorescenceFriday #cellbiology #bioart A neutrophilic HL-60 cell exhibits both sheet- and rosette-like dynamic pseudopods as it migrates in 3D through a collagen mesh. Here, the cell center is marked in yellow, and each pseudopod is marked with an orange ball of size…

A wonderful illustration of the different types of mechanical interactions that cells use to move collectively (and of how you can’t understand their relative contribution without force measurements). Congrats to the authors and thanks for having us on board!

No se pierdan este viernes a @Martina_Alamo_R , que nos presentará parte de su tesis de Doctorado sobre el rol del ATP en la activación de linfocitos B, en la Facultad de #CienciasBiologicasUC (Habrá pizza 🍕)

Penguins walking in 5x speed

#fluorescentfriday

I took this image with my lab partner @Peaceiton how part of our alliance #fluorescent #fluorescentfriday #bcell

Yes, our new paper by Aukie and @MiesvdStoel is now published at JCS! DLC1 provides negative feedback for YAP. journals.biologists.com/jcs/article/do… #mechanotransduction #angiogenesis #integrin #endothelial

B Cell activation #FluorescentFriday #superresolution #bcell #phdlife

A Review in @NatRevPhys summarizes the differences in several mechanical properties that play a role in human cancer development, at the cell and tissue levels. 🔒 go.nature.com/49jyc01

Image shows that the WW-NLS regulates YAP1-dependent cancer cell stemness. Yang, Wu, Pan et al. @FudanUni propose a new strategy to interfere with YAP1-dependent #cancer progression. hubs.la/Q02pBT5C0