Ryan O'Connell
@OConnellLab
Chief, Microbiology & Immunology Division, Department of Pathology at the University of Utah.
Our story made the cover of @JExpMed! So excited to share our work showing how tumor cells profoundly shape their local immune microenvironment @MihoTanakaMT
The cover of our June issue (hubs.la/Q03pvHwm0) shows a whole tumor formed after subcutaneous injection of a 1:1 mixture of CIT6-YFP (yellow) and CIT9-RFP (red) cell lines into mice carrying an inactivated Confetti cassette. From Tanaka et al. (hubs.la/Q03pvBtr0)
Interested in seeing how your tax dollars are NOT being used properly? Check out this NYTs article that has documented all the losses. Unhappy that this money isn't contributing to life saving research on cancer, heart disease, and neurological disorders? Call your senators!
The disappearing funds These are the nearly 2,500 N.I.H. grants that have been ended or delayed. nytimes.com/interactive/20…
We’re hiring! 🚨 My lab at @UUtah @UofUMandI is looking for a Senior Laboratory Specialist to join our research on glycobiology, metabolism, and inflammation. Apply here 👇 employment.utah.edu/salt-lake-city… #Glycotime #Hiring #ResearchCareers
Big news: I’ve joined the University of Utah @UUtah as an Associate Professor in the Department of Pathology, Division of Microbiology and Immunology @UofUMandI! Advancing glycobiology-driven research in metabolism and inflammation. Grateful to my UCSD colleagues. #Glycotime
Aloha from our M&I team attending #AAI2025 !
New 3i Investigator Article Alert!! OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination pubmed.ncbi.nlm.nih.gov/40299553/?utm_…
60 leading scientists from 10 institutions across 5 states across the Mountain West gathered at the Mountain West Microbiome Alliance Symposium to explore how our body’s microbes could unlock better health, smarter care, and the future of medicine. uofuhealth.utah.edu/newsroom/news/…
Congratulations Dr. Leung!
Congratulations to Daniel Leung, MD, MSc, on receiving the 2025 Outstanding Undergraduate Research Mentor Award from @uofuour. 🏆 Hear what this incredible recognition means to him. 👇 #meded #researchexcellence #mentorship #universityofutah @GlobalGutHealth
Congratulations Dr. Petrey! Keep up the great work!
Vitae is almost here. @UofUHealth annual celebration of research excellence features TED-style talks from some of our leading scientists, sharing their work on today’s most pressing health issues. uofuhealth.utah.edu/research/vitae
And thanks to @LotusLumphocyte @KenHu77 @KellyKersten8 @MaxKrummel @alexis_combes and all our co-authors for their incredible work to make this happen
We had the pleasure of hosting Dr. Chloe Villani @villanilab for the M&I Seminar Series today. We appreciated learning more about her research "Unraveling Immune Tolerance: Insights from Immune-Related Adverse Events in Immunotherapy". @UofUResearch @UofUHealth @UofUPathology
New research in mice shows gut microbiome shapes insulin-producing cells in infancy, with lifelong effects on diabetes risk. Scientists found specific microbes could help pancreas development & potentially restore function in adults with type 1 diabetes. bit.ly/4hjyxE7
This "showed how important the microbiota is during this very short early period of development.” Early-Life Gut Microbes May Protect Against Diabetes, Research in Mice Suggests via @RoundLabUtah @UofUPathology @UofUHealth Published in @ScienceMagazine healthcare.utah.edu/press-releases…
‘Stand Up for Science’ rally at state Capitol champions research, endeavor Gathering calls on Utahns to ‘uphold the integrity of science’ at an uncertain national moment for research deseret.com/utah/2025/03/0…
Our paper on early life fungi and diabetes has been published today! healthcare.utah.edu/press-releases…
Ecstatic to finally share the next installment of our work today in @ScienceMagazine! Check it out to learn how early-life microbes shape islet development and longterm metabolic health science.org/doi/10.1126/sc…
Our manuscript is just published in @emboreports! We introduce a new tool facilitating analysis of cancer #omics data. Check it here! embopress.org/doi/full/10.10… TCGEx: a powerful visual interface for exploring and analyzing cancer gene expression data | EMBO reports
"A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy" Congrats to everyone who contributed to this exciting work! ncbi.nlm.nih.gov/pubmed/39951377
A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy dlvr.it/THyckB
We are delighted to hear Dr. Tenthorey's seminar on "The Host Strikes Back: Strategies for Evolutionary Warfare with Viruses". @UofUPathology @UofUResearch @UUHSResearch