Neophytos Christodoulou

🎉🎉📖Our work on how intracellular calcium dynamics shape the mucociliary epithelium during Xenopus embryogenesis is now puplished @NatureComms . You can read the manuscript here: rdcu.be/ewTqQ . Many thanks to all the reviewers for their constructive input. 🐸🔬

Super excited that our paper is out. It describes a new mechanism for dealing with tissue crowding that does not involve cell extrusion. nature.com/articles/s4146…

Check out our new paper in @nature nature.com/articles/s4158…. We report genetic mechanisms of neural tube defects in patients. Spina bifida is also known as meningomyelocele (MM). Prior family-based and association studies found few linked genes, so we took a different approach.

Our paper is out! We show how the extracellular matrix guides body axis formation in mouse—and possibly human—embryos during early pregnancy. Grateful to @ZernickaGoetz @MZG_Lab for the chance to work with mouse, human, and stem cell–derived embryo models. nature.com/articles/s4146…

Warmest congratulations & thanks to brilliant member of our team @Caltech Wenqi Hu, collaborator @Roser Vento (not on X) & HDBR for a fantastic journey in bringing this unique resource. We hope it will be valuable as a reference point to build more powerful stem cell models

@the_Node @Dev_journal @Dev_Bio_Journal @Dev_Cell @V4Sdb @SocDevBio @InSDB_79 @cshlxeno @xenbase

New publication by Henrike Berns, lab members and the Schmidts lab @Uniklinik_Fr out at Disease Models & Mechanisms. journals.biologists.com/dmm/article/do… Congrats to Henrike and thanks to the Motivate program, @SFB1453_NephGen and @CIBSS for funding. 🐸 #xenopus #wnt #birthdefects #kidney

Very happy that my final PhD paper focussing on the maturation of the primitive into the visceral endoderm and its impact on embryo survival in mice is now published: sciencedirect.com/science/articl… Huge thanks to my PhD supervisor & my collaborators for making this project possible

1/6 New Preprint Reptiles comprise ~23,000 species with an incredible range of diversity. The basis is laid during embryogenesis but severely understudied. We study the brown anole & describe its early embryogenesis for the first time: biorxiv.org/content/10.110…

While we're at it: We are looking for 2 postdocs. One with experience in dev. Biol (pref. With mouse experience) and one with bioinformatics / modeling / multi-omics experience. Exceptional PhD candidates will be also considered for the project via IMPRS @mpi_ie recruitment.

Another preprint from the lab and a collaboration with Miriam Schmidts and her lab from @Uniklinik_Fr pediatrics. This work was carried out mostly by fantastic MD MOTIVATE student Henrike Berns. Funded by @dfg_public @CIBSS_UniFR and @SFB1453_NephGen. biorxiv.org/content/10.110…

We all take for granted that we can just reprogram cells- iPSCs are ubiquitous. But DYK that this was first demonstrated in frogs? Talk about a #xensight! Sir John Gurdon showed that a differentiated intestinal nucleus can be reprogrammed when put into an enucleated egg- in 1962!

Our latest #Ichthyosporean #EvoDevo story, led by M. Olivetta @ChandniBhickta @NChiaruttini & in co. with @burnsajohn is finally out @Nature . Link⏩: nature.com/articles/s4158… Preprint⏩: biorxiv.org/content/10.110… 1/5)

EXCITED to unroll this 🧵 on our new story on the metabolic licensing of animal development... How did we even get here..? shorturl.at/vuCIh Early embryo is thought of a pre-set machine that's set to go once it's fertilized - check out this gorgeous 📽️from Phil Keller!

New preprint from the lab 🙌 @biorxivpreprint. We found new foxi1 functions in multipotent mucociliary progenitors in #xenopus. 🐸 biorxiv.org/content/10.110… Congrats to 3 first authors @_bowden @MagdaBrislinger @Mona__Hansen & team! @CIBSS_UniFR @SFB1453_NephGen @dfg_public

DYK we can make thousands of half-mutant (down the midline) embryos in Xenopus every day? One mating pair lays 4000+ embryos each day- inject whatever you like into 1 cell at the 2-cell stage and watch it be inherited into just one half of the 🐸!