Mick lab
@MickLab
Using biochemistry, cell biology, proteomics and imaging techniques to unravel the molecular functions of mammalian primary #cilia. @mick-lab.bsky.social
We are super-excited to see our first original paper published in @JCellBiol. Fantastic collaboration with @KalocsayMarian @GygiLab @MaxNACHURY to establish quantitative, time-resolved #cilia #proteomics. Very proud of our first PhD student Elena May! rupress.org/jcb/article/22…
A new paper reports that the primary mechanism of capsaicin entry into the vanilloid-binding site of TRPV1 is a targetable hydrophobic tunnel at the TRPV1-membrane interface nature.com/articles/s4158…
Militsin, Palty et al. reveal novel crosstalk btwn STIM proteins & IP3Rs, whereby STIM activation alters the spatial pattern of IP3R-mediated Ca2+ release, shifting it from a promigratory localized signal to a diffuse, migration-suppressing signal hubs.ly/Q03z58_80
Save the date! March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? 🥳 Stay tuned for more info!
👨🎓 🇩🇪👩🎓 Further your research career by doing your PhD in Germany❗ Start your search for currently open PhD positions at the DAAD online database PhDGermany.de
The abstract submission deadline for the 2nd edition of our #EMBOLipidDroplets Workshop (21-26 September 2025) is approaching. Check out the agenda with an amazing lineup of speakers and submit your abstract before 10 June 2025! @EMBO @Co_Biologists meetings.embo.org/event/25-lipid…
Save the date dear #cilia #centrosome fans🙂 The 8th Czech Cilia meeting will happen this year in Brno on 17th of June with keynote speaker Ruxandra Bachmann-Gagescu. No registration fees👏please RT🌼
Huo, Wang et al. reveal that #adipocytes experiencing endoplasmic reticulum stress secrete #ceramide in lipoprotein form to #hepatocytes, activating the unfolded protein response by reducing membrane fluidity. hubs.ly/Q03dw31h0 #ER_literature
#Vimentin filament transport and organization revealed by single-particle tracking and 3D FIB-SEM. New study from Bhuvanasundar Renganathan, Andrew Moor, Vladimir Gelfand @NUFeinbergMed and colleagues: hubs.la/Q03b6C7f0 #Cytoskeleton #Microscopy
Dear #LipidDroplet friends, We are so much looking forward to the 2nd edition of our #EMBOLipidDroplets Workshop. Join us 21-26 September 2025 at beautiful Costa Brava! Abstract submission deadline is 10 June 2025. @EMBO @Co_Biologists
Check out our latest work using the AID2 system to control the levels of an essential protein in mice. Congrats to the entire team, especially @SladkyValentina and Margaret Strong science.org/doi/10.1126/sc…
From Tom Maniatis, a succinct summary of how American science infrastructure has been supported and the devastating effects of cutting down to a federal 15% cap will have: "The impact of this decision, if implemented, will be immediate and far-reaching." cell.com/cell/fulltext/…
RAB-10 cooperates with EHBP-1 to capture vesicular carriers during post-Golgi exocytic trafficking, say Shuai Liu, Jie Wei, Yanling Yan, Anbing Shi and colleagues (Huazhong University of Science and Technology): hubs.la/Q037LKPP0 #Membrane #Trafficking #Biochemistry
Die Herausforderung in der Außenpolitik liegt darin, dass wir im Kalten Krieg zumindest eine gewisse Stabilität hatten - durch das Jalta-Abkommen waren die Einflusssphären klar aufgeteilt, auch wenn das nicht schön war. Heute sieht die Welt ganz anders aus: Das Sowjetsystem…
Cells secrete proteins that cannot enter the ER–Golgi secretory pathway. Curwin, Kurokawa et al show that Golgi membranes are recycled to create new compartments that lack Golgi-specific glycosyltransferases & function to collect & sort cargo for secretion hubs.la/Q038Ny920
Mutually independent and cilia-independent assembly of IFT-A and IFT-B complexes at mother centriole dlvr.it/TJFmCZ
Chemoproteomic profiling of protein dopamination in the mouse brain reveals a protective role of dopamine in regulating the function of microtubule-associated protein Tau nature.com/articles/s4158…
Protein engineering at its best.
Today we report the directed evolution of HUH (a sequence-sequence covalent protein tag for ssDNA labeling) into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA…
Registration is open for our summer @FASEBorg #Ferroptosis Conference July 27 - 31, 2025. We have a terrific line up of speakers and it's going to be amazzzing! Come join us for this historic first meeting! Please help spread the word. 🤩 shorturl.at/QA6T1
”It's really the love of craft which binds the community of scientists together.” - 2017 medicine laureate Michael Rosbash during the Nobel Week Dialogue 2024. Rosbash argued that scientists - and sportspeople - should not be driven solely by awards and recognition but instead…