Matthew Feinstein

Drs. @abigeorgeyates1, Cameron McAlpine (@cam_phd), and colleagues at @IcahnMountSinai uncover a disease stage-specific relationship between lifestyle, #myelopoiesis, and neuroinflammation. Read about it in @NatureComms! 👇 🔓 go.nature.com/4jHd8pZ

Galán et al found that #cDC1s are proatherogenic via local #immunity & developed a novel #immunotherapy for #atherosclerosis based on cDC1-targeted lipid #nanoparticles. Learn more at ahajrnls.org/3GVqEZy @Sancholab @SBiomagMfb @aramiro_ramiro @CarregalSusana

reprogramming cells with transcription factors is our most expressive tool for engineering cell state traditionally, we found TFs by ~guesswork @icmlconf we're sharing @newlimit's SOTA AI models that can design reprogramming payloads by building on molecular foundation models

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s4158… #OpenAccess at @Nature @CNIC_CARDIO #microbiome #CVD

Acute Immune Cell Dynamics During Myocardial Infarction and Their Association with Mortality mdpi.com/3393172 #mdpiijms via @IJMS_MDPI. Thanks to @MattFeinsteinMD for all his mentorship through the years!

Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in @Nature. This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at @CRGenomica nature.com/articles/s4158…

And that’s a wrap! Huge thank you to all the speakers, moderators, poster presenters, and attendees at the 2025 Gordon Research Conference on Atherosclerosis. A fantastic meeting and even better community! Incredible to work with Esther Lutgens. See you in 2027!

Congrats to @HAvgousti on his #focis2025 travel grant & presentation, and 🍻 Boston showing off in the heat! @FOCISimmunology @thorplab @immunology_nu

nature.com/articles/s4156…

👏🏼 @thorplab

🎧 New #BreakthroughsPodcast Episode! Ed Thorp, PhD, discusses his partnership with @MattFeinsteinMD, and how @thorplab's #BasicScience research can respond to the needs of patients. Learn more about his recent discovery by listening to the episode. 🔗 spr.ly/60134rFBW

TET2 mutant clonal hematopoiesis promotes heart failure with preserved ejection fraction via proinflammatory pathways @ambarish4786, @AmandaTong2013, @SChung_Lab, @UTSWMedCenter @mattsegar @daou_daniel @huwenhuo @PremnathNaveen ahajournals.org/doi/full/10.11…

Mercedes Carnethon, PhD (@MCarnethon), has taken the baton as the new chair of #PreventiveMedicine and is off and running at full speed! 👏 spr.ly/60144JsGa

#ICYMI: HFpEF Stem Cells @josephahill @HFpEF @MattFeinsteinMD @PilarAlcaidePhD @GlintonKris @gabrieleschiat1 @Matt_DeBerge

Happy to share a new review: Neural Mechanisms in Cardiovascular Health and Disease | Circulation Research ahajournals.org/doi/full/10.11… Part of a series on Inter-organ communication! Great teamwork @DimmelerLab @CVR_TomaszGuzik @cam_phd D Carnevale, S Engelhardt, KA Ziegler

Laissez les bons temps rouler at Scientific Sessions! It’s almost time to submit your science, save your spot, and visit New Orleans for #AHA25, the biggest cardiovascular event of the year. Mark your calendars ⬇️ @JoChikweMD @bnallamo

Epigenetic modifications in distinct immune and other cell types may act in concert to influence the progression of atherosclerosis. ahajournals.org/doi/full/10.11…

Congratulations to @NUCATSInstitute Career Development Award Scholar alumna Sadiya Khan, MD, MSCI, who has been inducted into @the_asci, one of the oldest medical honor societies in the United States — bit.ly/NUCATS-ASCI

A specialized spleen macrophage population—expressing the markers CD169 and Tim4—mobilizes after MI to drive repair, clear neutrophils & reduce HF risk. A new frontier in cardioprotection via the cardiosplenic axis. @ssbansal_pshvi @SDPrabhuMD ahajournals.org/doi/full/10.11…

Hemoglobin-stimulated macrophages drive plaque instability through multiple mechanisms: promoting leaky vessels, thinning protective caps, and preventing calcification. Key insights for cardiovascular diseases! #CVD #macrophage #atherosclerosis ahajrnls.org/44XkoK9