Lucas Farnung
@LucasFarnung
Assistant Professor @HarvardCellBio. Transcription & Chromatin; Biochemistry, X-ray & Cryo-EM. Views are my own.
Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @MarkertJon tinyurl.com/setd2
How do chromatin remodelers use #IDRs to find their TF binding partners? Check out San’s tweetorial about SWI/SNF (cBAF) subunit ARID1A and β-catenin, now online at Mol Cell
Excited to share our new Molecular Cell paper! We show that β-catenin is an adaptor that links canonical BAF (cBAF) with binding partners via IDR-domain interactions. (1/7) cell.com/molecular-cell…
🎥 Our @harvard undergrad Yerosen Daba is running the Harvard College Instagram page today. Check out his story here: instagram.com/stories/harv... And learn what we do in the Farnung lab (and perhaps you get to meet the man, the myth, the legend aka Boltzmann too)! 📸⚡
First PhD candidate (congrats, Dr. James!) to graduate today and check out this beautiful nucleosome/ocean cake made for the occasion by PhD candidate Della Syau 🎂🍰
Congratulations to 🎓 Dr. Allison James 🎉. Allison is the first PhD candidate to graduate from the Farnung Lab!
With great sadness and deep regret, we have to inform you that our department director and highly esteemed colleague Philippe Bastiaens @maxplanckpress passed away suddenly and unexpectedly on 15th of May.
Sending a mountain of gratitude to all the sponsors of the 2025 Timmerman Traverse, who helped our Everest Base Camp trekkers exceed their goal and raise nearly $800k for cancer research! 🏔 damonrunyon.org/news/entries/8…
This support is highly appreciated! From personal experience: Transatlantic cooperation is a pillar of the scientific enterprise!
Max Planck President Patrick Cramer @mpgpresident has written an open letter to the President of @Harvard, expressing his full support to the University & its stance against demands from the Trump administration to change its policies in order to retain federal funding…
Worth noting: 🇩🇪 invested 3.11% of GDP in R&D in 2023. The new 3.5% target for 2030 is only a marginal increase—and was already set for 2025. Ambition looks rather limited.
Interesting science goals from Germany’s new coalition agreement (CDU/CSU/SPD): 🇩🇪 100,000 GPU AI cluster 🌍 “1,000 minds” program for global talent 📜 Reform of fixed-term academic contracts 📈 3.5% of GDP for R&D by 2030 ⚛️ Target: First working fusion reactor to be built in 🇩🇪
Interesting science goals from Germany’s new coalition agreement (CDU/CSU/SPD): 🇩🇪 100,000 GPU AI cluster 🌍 “1,000 minds” program for global talent 📜 Reform of fixed-term academic contracts 📈 3.5% of GDP for R&D by 2030 ⚛️ Target: First working fusion reactor to be built in 🇩🇪
🚨New paper🚨Our new study with @Phil_Cole_Lab uncovers how SIRT6 dynamically adapts structurally and enzymatically to target diverse histone acylations (e.g., H3K27ac) within nucleosomes. @ZhipengA @MarkertJon doi.org/10.1016/j.jbc.… #Chromatin #SIRT6 #CryoEM