Marcus Goncalves
@MarcusDGon
MD/PhD Endocrinologist and scientist. Cancer metabolism, cachexia, insulin, PI3K, diabetes, obesity. GI Villi lover. Metabolic Consulting. NYJ/NYY/NYCFC fan.
3D shape changes following a a dual GIP and GLP-1 receptor agonist from the GOAT @heymsfield These are very easy to acquire in the clinic and perform strongly against DXA and BIA. nature.com/articles/s4136…
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction science.org/doi/10.1126/sc…
Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin 😍 science.org/doi/10.1126/sc…
Good grief
NCI Interim Funding Policy: “With these considerations, we expect to fund through the 4th percentile for those established investigator applications.” “It is expected that funds will be available to reach the 10th percentile for those Early Stage Investigator applications.” 😢
Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia: @CellCellPress @BerrielDiaz congrats all! cell.com/cell/fulltext/…
There is now a @NIH extramural nexus news article that addresses this policy change titled: “How Does the NIH Initiative to Prioritize Human-Based Research Affect Research Proposing the Use of Laboratory Animals?” grants.nih.gov/news-events/ni…
Highly reliable sources tell me @NIH will still fund purely animal model grants (new ones too). NOAs (notice of awards) will be more human focused & justification for animal models must be made but $ for new & funded animal grants will continue. @Nature @ScienceMagazine @HHSGov
See if your child qualifies for the Shape Up! Keiki research study. We are seeking individuals 5 years of age or younger. You can earn up to $125 for your time. Learn more: pbrc.edu/ShapeUpKeiki
I’m excited to announce my new book FOOD INTELLIGENCE coauthored with brilliant journalist @juliaoftoronto! Cutting through the confusion about diet & health, #FoodIntelligence describes the fascinating science of how food both nourishes and harms us. penguinrandomhouse.com/books/671334/f……
What are the relative impact of diet vs physical activity on the global obesity crisis? New paper out @pnas uses the DLW Database with 4000+ participants across 34 populations to investigate Obesity & Energy Expenditure Across the Economic Spectrum. Open access link below!🧵1/
A phase 1 safety and feasibility trial of a ketogenic diet plus standard of care for patients with recently diagnosed glioblastoma @ljamaral1 @SFreedlandMD #JethroHu nature.com/articles/s4159…
Guilty as charged? The role of unprocessed foods and development of #obesity @NatureRevEndo nature.com/articles/s4157…
Hey Muscle And Metabolism Folks on Twitter, @LykkeSylow and I are looking for a Postdoc who is interested in applying for a prestigious @DDEA_Denmark fellowship with us. More details in the picture attached. Please share widely! @MYOTWlTTER
My third baby #oncoendocrinology #SIG @TheEndoSociety. Now at close to 400plus members. #ENDO2025 It has been an honor to start this and raise it from 0 to 1 to now in the 100s. We are supporting oncology practices around the world with onco endocrinologists 🌎join us!
🍯Happy to share our New preprint: Metabolic Adaptations of Prostate Cancer Cells Under Chronic Fructose Stimulation biorxiv.org/content/10.110…